Division of Nephrology and Hypertension, Department of Medicine, and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Division of Nephrology and Hypertension, Department of Medicine, and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kidney Int. 2022 Aug;102(2):228-230. doi: 10.1016/j.kint.2022.05.009.
Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23-FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.
慢性肾脏病患者中过量的成纤维细胞生长因子 23（FGF23）信号会导致左心室肥厚。在本期杂志中，Yanucil 等人研究了可溶性 klotho 和肝素与 FGF23 和 FGF 受体亚型的相互作用。他们得出结论，肝素促进 FGF23-FGF 受体亚型 4 的相互作用和 FGF23 的致病作用，这支持了肝素在 FGF23 介导的慢性肾脏病左心室肥厚发病机制中的重要作用。
