Xu Zhi-Heng, Zhang Meng-Han, Wang Jian
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Institute of Modern Languages and Linguistics, Fudan University, Shanghai 200433, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Jul;53(4):726-731. doi: 10.12182/20220760304.
Screening for and identifying patients with Parkinson's disease (PD) at an early stage and forming accurate diagnosis of PD during the course of the progression of the disease are of essential importance but still remain challenging for the clinical diagnosis and treatment of PD. One of the common clinical manifestations of PD is speech impairment, or voice impairment. Thanks to the recent advances in the field of acoustic analysis, a large number of acoustic parameters have been proposed for evaluating speech impairment quantitatively. Early identification and accurate diagnosis of PD was henceforth made possible through the application of speech acoustic analysis. Herein, we summarized the latest research findings on the application of acoustic analysis in PD diagnosis. We reported some acoustic parameters commonly used in the evaluation of voice impairment in PD patients. Then, we presented the diagnostic value of acoustic analysis in developing accurate diagnosis, early screening and differential diagnosis. Furthermore, we discussed the drawbacks and prospects of current studies, intending to enhance understanding of acoustic analysis of PD patients and its potential diagnostic values.
在帕金森病(PD)早期筛查和识别患者,并在疾病进展过程中对PD进行准确诊断,对于PD的临床诊断和治疗至关重要,但仍然具有挑战性。PD常见的临床表现之一是言语障碍或嗓音障碍。由于声学分析领域的最新进展,已经提出了大量声学参数用于定量评估言语障碍。因此,通过言语声学分析实现了对PD的早期识别和准确诊断。在此,我们总结了声学分析在PD诊断应用方面的最新研究结果。我们报告了一些常用于评估PD患者嗓音障碍的声学参数。然后,我们阐述了声学分析在进行准确诊断、早期筛查和鉴别诊断方面的诊断价值。此外,我们讨论了当前研究的不足和前景,旨在加深对PD患者声学分析及其潜在诊断价值的理解。