镉暴露与男性睾酮水平相关：一项来自中国国家人体生物监测的横断面研究。
Cadmium exposure is associated with testosterone levels in men: A cross-sectional study from the China National Human Biomonitoring.
作者信息
Qiu Yidan, Lv Yuebin, Zhang Miao, Ji Saisai, Wu Bing, Zhao Feng, Qu Yingli, Sun Qi, Guo Yanbo, Zhu Yuanduo, Lin Xiao, Zheng Xulin, Li Zheng, Fu Hui, Li Yawei, Song Haocan, Wei Yuan, Ding Liang, Chen Guangdi, Zhu Ying, Cao Zhaojin, Shi Xiaoming
机构信息
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; Department of Big Data in Health Science, School of Public Health, Zhejiang University, Hangzhou, Zhejiang, China.
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
出版信息
Chemosphere. 2022 Nov;307(Pt 2):135786. doi: 10.1016/j.chemosphere.2022.135786. Epub 2022 Jul 21.
BACKGROUND
Sex hormone disorders can cause adverse health consequences. While experimental data suggests that cadmium (Cd) disrupts the endocrine system, little is known about the link between Cd exposure and sex hormones in men.
METHODS
We measured blood cadmium (B-Cd), urine cadmium (U-Cd), serum testosterone and serum estradiol in men aged ≥18 years old participating in the China National Human Biomonitoring program, from 2017 to 2018. Urine cadmium adjusted for creatinine (Ucr-Cd) and the serum testosterone to serum estradiol ratio (T/E) were calculated. The association of Cd exposure to serum testosterone and T/E in men was analyzed with multiple linear regression models.
RESULTS
Among Chinese men ≥18 years old, the weighted geometric mean (95% CI) of B-Cd and Ucr-Cd levels were 1.23 (1.12-1.35) μg/L and 0.53 (0.47-0.59) μg/g, respectively. The geometric means (95% CI) of serum testosterone and T/E were 18.56 (17.92-19.22) nmol/L and 143.86 (137.24-150.80). After adjusting for all covariates, each doubling of B-Cd level was associated with a 5.04% increase in serum testosterone levels (β = 0.071; 95%CI: 0.057-0.086) and a 4.03% increase in T/E (β = 0.057; 95%CI: 0.040-0.075); similar findings were found in Ucr-Cd.
CONCLUSIONS
In Chinese men, Cd may be an endocrine disruptor, which is positively associated with serum testosterone and T/E.
背景
性激素紊乱会对健康造成不良影响。虽然实验数据表明镉（Cd）会扰乱内分泌系统，但关于男性镉暴露与性激素之间的联系却知之甚少。
方法
我们测量了2017年至2018年参加中国国家人体生物监测项目的18岁及以上男性的血镉（B-Cd）、尿镉（U-Cd）、血清睾酮和血清雌二醇。计算了校正肌酐后的尿镉（Ucr-Cd）以及血清睾酮与血清雌二醇的比值（T/E）。采用多元线性回归模型分析男性镉暴露与血清睾酮和T/E之间的关联。
结果
在18岁及以上的中国男性中，B-Cd和Ucr-Cd水平的加权几何平均值（95%CI）分别为1.23（1.12 - 1.35）μg/L和0.53（0.47 - 0.59）μg/g。血清睾酮和T/E的几何平均值（95%CI）分别为18.56（17.92 - 19.22）nmol/L和143.86（137.24 - 150.80）。在对所有协变量进行校正后，B-Cd水平每增加一倍与血清睾酮水平增加5.04%（β = 0.071；95%CI：0.057 - 0.086）以及T/E增加4.03%（β = 0.057；95%CI：0.040 - 0.075）相关；在Ucr-Cd中也发现了类似结果。
结论
在中国男性中，镉可能是一种内分泌干扰物，与血清睾酮和T/E呈正相关。
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