Blackie Alexis C, Foley Daniel J
School of Physical and Chemical Sciences, University of Canterbury, Christchurch, New Zealand.
School of Physical and Chemical Sciences, University of Canterbury, Christchurch, New Zealand.
Bioorg Med Chem. 2022 Sep 15;70:116914. doi: 10.1016/j.bmc.2022.116914. Epub 2022 Jul 6.
The Cdc2-like kinases (CLKs 1-4) are involved in regulating the alternative splicing of a variety of genes. Their activity contributes to important cellular processes such as proliferation, differentiation, apoptosis, migration, and cell cycle regulation. Abnormal expression of CLKs can lead to cancers; therefore, pharmacological inhibition of CLKs may be a useful therapeutic strategy. This review summarises what is known about the roles of each of the CLKs in cancerous cells, as well as the effects of relevant small molecule CLK inhibitors.
类Cdc2激酶（CLKs 1 - 4）参与调控多种基因的可变剪接。它们的活性有助于细胞增殖、分化、凋亡、迁移和细胞周期调控等重要细胞过程。CLKs的异常表达可导致癌症；因此，对CLKs进行药理学抑制可能是一种有效的治疗策略。本综述总结了目前已知的CLKs在癌细胞中的作用，以及相关小分子CLK抑制剂的作用效果。
