Yang Xiaoli, Yin Hua, Zhang Deyu, Peng Lisi, Li Keliang, Cui Fang, Xia Chuanchao, Li Zhaoshen, Huang Haojie
Department of Gastroenterology, General Hospital of Ningxia Medical University, Ningxia Medical University, Yinchuan, China.
Department of Gastroenterology, Changhai Hospital, Navy/Second Military Medical University, Shanghai, China.
Front Med (Lausanne). 2022 Jul 6;9:898455. doi: 10.3389/fmed.2022.898455. eCollection 2022.
Cathepsin B (CTSB) is a lysosomal protease implicated in the progression of various diseases. A large number of CTSB-related studies have been conducted to date. However, there is no comprehensive bibliometric analysis on this subject. In our study, we performed quantitative analysis of CTSB-related publications retrieved from the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (reference period: 2011-2021). A total of 3,062 original articles and reviews were retrieved. The largest number of publications were from USA ( = 847, 27.66%). The research output of each country showed positive correlation with gross domestic product (GDP) ( = 0.9745, < 0.0001). Active collaborations between countries/regions were also observed. Reinheckel T and Sloane BF were perhaps the most impactful researchers in the research landscape of CTSB. Plos ONE was the most prevalent (119/3,062, 3.89%) and cited journal (3,021 citations). Comprehensive analysis of the top citations, co-citations, and keywords was performed to acquire the theoretical basis and hotspots of CTSB-related research. The main topics included CTSB-related cancers and inflammatory diseases, CTSB-associated cell death pattern, and the applications of CTSB. These results provide comprehensive insights into the current status of global CTSB-related research especially in pancreas, which is worthy of continued follow-up by practitioners and clinicians in this field.
组织蛋白酶B（CTSB）是一种溶酶体蛋白酶，与多种疾病的进展有关。迄今为止，已经开展了大量与CTSB相关的研究。然而，尚未有关于该主题的全面文献计量分析。在我们的研究中，我们对从科学网核心合集的科学引文索引扩展版（SCIE）中检索到的与CTSB相关的出版物进行了定量分析（参考期：2011年至2021年）。共检索到3062篇原创文章和综述。发表文章数量最多的国家是美国（n = 847，占27.66%）。每个国家的研究产出与国内生产总值（GDP）呈正相关（r = 0.9745，P < 0.0001）。还观察到国家/地区之间的积极合作。Reinheckel T和Sloane BF可能是CTSB研究领域中最具影响力的研究人员。《公共科学图书馆·综合》是最常见的期刊（119/3062，占3.89%）和被引用次数最多的期刊（3021次引用）。对顶级引用、共被引和关键词进行了综合分析，以获取CTSB相关研究的理论基础和热点。主要主题包括与CTSB相关的癌症和炎症性疾病、与CTSB相关的细胞死亡模式以及CTSB的应用。这些结果为全球CTSB相关研究的现状提供了全面的见解，尤其是在胰腺方面，值得该领域的从业者和临床医生持续关注。
