Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China.
Department of Clinical Laboratory, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
Comput Math Methods Med. 2022 Jul 13;2022:3889588. doi: 10.1155/2022/3889588. eCollection 2022.
Esophageal cancer is a kind of cancer with high morbidity and mortality, which is accompanied by a profound poor prognosis. A prognostic nutritional index, based on serum albumin levels and peripheral lymphocyte count, has been confirmed to be significantly associated with various cancers. This study was aimed at exploring the prognostic significance of PNI in the overall survival prognosis of patients with esophageal cancer. As a real-world study based on the big database, clinical data of 2661 patients with esophageal cancer were evaluated retrospectively, and the individuals were randomly divided into training and testing cohorts. In these two cohorts, patients are classified into a high-risk group (PNI < 49) and a low-risk group (PNI ≥ 49). Univariate and multivariate analyses were performed to analyze the independent risk factors for the prognosis of esophageal cancer patients by using the Cox proportional hazards regression model. In this study, whether in the training cohort or the testing cohort, according to the univariate analysis, gender, tumor size, tumor grade, T stage, N stage, M stage, TNM stage, and PNI were significantly correlated with overall survival. Furthermore, the multivariate analysis showed that gender, T stage, N stage, M stage, TNM stage, and PNI were independent prognostic risk factors for esophageal cancer. PNI can be regarded as an independent prognostic factor combined with gender, T stage, N stage, M stage, and TNM stage, and it might be a novel reliable biomarker for esophageal cancer.
食管癌是一种发病率和死亡率都很高的癌症，其预后极差。基于血清白蛋白水平和外周血淋巴细胞计数的预后营养指数已被证实与多种癌症显著相关。本研究旨在探讨 PNI 在食管癌患者总生存预后中的预测意义。作为一项基于大数据库的真实世界研究，回顾性评估了 2661 例食管癌患者的临床数据，并将患者随机分为训练队列和测试队列。在这两个队列中，患者被分为高风险组（PNI<49）和低风险组（PNI≥49）。采用 Cox 比例风险回归模型对食管癌患者预后的独立危险因素进行单因素和多因素分析。在本研究中，无论是在训练队列还是在测试队列中，根据单因素分析，性别、肿瘤大小、肿瘤分级、T 分期、N 分期、M 分期、TNM 分期和 PNI 与总生存均显著相关。此外，多因素分析表明，性别、T 分期、N 分期、M 分期、TNM 分期和 PNI 是食管癌的独立预后危险因素。PNI 可作为一个独立的预后因素与性别、T 分期、N 分期、M 分期和 TNM 分期相结合，可能是一种新的可靠的食管癌标志物。
