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紫草素的结构与抗妇科恶性肿瘤研究进展

Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin.

作者信息

Ke Li-Na, Kong Ling-Qi, Xu Huan-Huan, Chen Qin-Hua, Dong Yun, Li Bin, Zeng Xiao-Hua, Wang Hong-Mei

机构信息

Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China.

Hubei Key Laboratory of Wudang Local Chinese Medicine Research, School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, China.

出版信息

Front Chem. 2022 Jul 8;10:935894. doi: 10.3389/fchem.2022.935894. eCollection 2022.

DOI:10.3389/fchem.2022.935894
PMID:35873044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9304652/
Abstract

Gynecological malignancy seriously threatens the physical and mental health of women. Shikonin is a naphthoquinone compound with a variety of biological activities. Studies have shown that shikonin can inhibit cell proliferation, promote cell apoptosis and induce cell necrosis. And in recent years, shikonin are also being increasingly used for the study of gynecological malignant diseases. Therefore, we reviewed the mechanism of action and structure optimization of shikonin in gynecological malignant tumors, in order to provide some reference for further research and development of related drug.

摘要

妇科恶性肿瘤严重威胁着女性的身心健康。紫草素是一种具有多种生物活性的萘醌类化合物。研究表明，紫草素可抑制细胞增殖、促进细胞凋亡并诱导细胞坏死。近年来，紫草素也越来越多地用于妇科恶性疾病的研究。因此，我们综述了紫草素在妇科恶性肿瘤中的作用机制及结构优化，以期为相关药物的进一步研发提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/b8b4287eeba5/fchem-10-935894-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/bcfe2bfae1cc/fchem-10-935894-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/3b2a0323f4d1/fchem-10-935894-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/a094506c92b7/fchem-10-935894-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/9a4c271524ba/fchem-10-935894-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/b8b4287eeba5/fchem-10-935894-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/bcfe2bfae1cc/fchem-10-935894-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/3b2a0323f4d1/fchem-10-935894-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/a094506c92b7/fchem-10-935894-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/9a4c271524ba/fchem-10-935894-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e97/9304652/b8b4287eeba5/fchem-10-935894-g005.jpg

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