Comparative Genomic Analysis of the Human Pathogen Provides Insight Into the Identification of Antimicrobial Resistance Genotypes and Potential Virulence Traits.

Recent studies suggest that may be the cause of several diseases in humans including sepsis and bacteremia making the bacterium as a previously underappreciated human pathogen. However, very little is known about the pathogenicity and genetic potential of ; therefore, it is necessary to conduct systematic studies to gain a deeper understanding of its virulence characteristics and treatment options. In this study, the entire genetic repertoire of all publicly available genomes was examined including characterization of bacteriophage content, antibiotic resistome, and putative virulence profile. The pan-genome of comprises 3819 genes with 1622 core genes (43%) indicating a putative metabolic conserved species. Furthermore, analysis indicated presumed resistome expansion as defined by the presence of genome-encoded transposons and bacteriophages. While macrolide resistance genes and are located within the core genome, additional antimicrobial resistance genotypes for tetracycline (, and ), aminoglycosides (,, , and )), sulfonamide (), streptomycin (), chloramphenicol (), and beta-lactamase () are distributed among the accessory genome. Notably, our data indicate that the type strain DSM 18708 does not encode any additional clinically relevant antibiotic resistance genes, whereas drug resistance is increasing within the clade. This trend should be monitored with caution. To the best of our knowledge, this is the first comprehensive genome analysis of this species, providing new insights into the genome of this opportunistic human pathogen.