Cai Jia, Wei Wei, Zhao Liansheng, Li Mingli, Li Xiaojing, Liang Sugai, Deng Wei, Du Xiang Dong, Wang Qiang, Guo Wan-Jun, Ma Xiaohong, Sham Pak C, Li Tao
Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Psychiatry. 2022 Jul 7;13:925204. doi: 10.3389/fpsyt.2022.925204. eCollection 2022.
With less exposure to environmental and medication influences, individuals with early-onset schizophrenia (EOS) may provide valuable evidence to study the pathogenesis and phenotypic pattern of schizophrenia.T1-weighted magnetic resonance images were collected in 60 individuals with EOS and 40 healthy controls. Voxel-based morphometry and surface-based morphometry analyzes were performed. Gray matter volume, cortical thickness and cortical surface area were compared between the EOS and healthy controls and among schizophrenia subgroups (with or without family history of schizophrenia). Compared with healthy controls, the EOS group had reduced gray matter volume in the bilateral middle temporal gyrus and reduced cortical thickness in several brain regions. The sporadic early onset schizophrenia and the familial early onset schizophrenia showed different brain structure morphology. These findings suggest that abnormal brain structure morphology, especially in the temporal and frontal lobes, may be an important pathophysiological feature of EOS.
由于早期精神分裂症（EOS）患者较少受到环境和药物影响，他们可能为研究精神分裂症的发病机制和表型模式提供有价值的证据。对60例EOS患者和40名健康对照者进行了T1加权磁共振成像检查。进行了基于体素的形态学分析和基于表面的形态学分析。比较了EOS患者与健康对照者之间以及精神分裂症亚组（有或无精神分裂症家族史）之间的灰质体积、皮质厚度和皮质表面积。与健康对照者相比，EOS组双侧颞中回灰质体积减少，多个脑区皮质厚度降低。散发性早发性精神分裂症和家族性早发性精神分裂症表现出不同的脑结构形态。这些发现表明，脑结构形态异常，尤其是颞叶和额叶，可能是EOS的一个重要病理生理特征。
