Kim Eunghee, Ban Choongjin, Kim Sang-Oh, Lim Seokwon, Choi Young Jin
Department of Agricultural Biotechnology, Seoul National University, Gwanakgu, Seoul, 08826 Republic of Korea.
Department of Environmental Horticulture, University of Seoul, Dongdaemungu, Seoul, 02504 Republic of Korea.
Food Sci Biotechnol. 2022 May 20;31(8):1009-1026. doi: 10.1007/s10068-022-01093-0. eCollection 2022 Jul.
Imbalanced nutrition in modern society is one of the reasons for disorders, such as cancer, cardiovascular disease, and diabetes, which have attracted the interest in bioactives (particularly polyphenols) to assist in the balanced diet of modern people. Although stability can be maintained during preparation and storage, the ingested polyphenols undergo harsh gastrointestinal digestion processes, resulting in limited bioaccessibility and low gut-epithelial permeation and bioavailability. Several lipid-based formulations have been proposed to overcome these issues. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have also been highlighted as carrier systems for the oral delivery of lipophilic bioactives, including polyphenols. This paper summarizes the research on the ingredients, production methods, post-processing procedures, general characteristics, and advantages and disadvantages of SLNs and NLCs. Overall, this paper reviews the applications and perspectives of polyphenol-loaded SLNs and NLCs in foods, as well as their regulation, production, storage, and economic feasibility.
现代社会中营养不均衡是引发癌症、心血管疾病和糖尿病等病症的原因之一，这引发了人们对生物活性物质（尤其是多酚类）的兴趣，以助力现代人实现均衡饮食。尽管在制备和储存过程中多酚类物质的稳定性可以得到维持，但摄入的多酚类物质会经历严苛的胃肠道消化过程，导致生物可及性有限、肠道上皮渗透率低以及生物利用度不高。人们已提出多种基于脂质的制剂来解决这些问题。固体脂质纳米粒（SLNs）和纳米结构脂质载体（NLCs）也被视为用于口服递送包括多酚类在内的亲脂性生物活性物质的载体系统。本文总结了有关固体脂质纳米粒和纳米结构脂质载体的成分、生产方法、后处理程序、一般特性以及优缺点的研究。总体而言，本文综述了负载多酚的固体脂质纳米粒和纳米结构脂质载体在食品中的应用及前景，以及它们的监管、生产、储存和经济可行性。
