Liu Qi-Hong, Ke Xiao, Xiao Cenxin
The Second People's Hospital Affiliated to Fujian University of Chinese Medicine, Fuzhou 350003, China.
Fujian Clinical Medical Research Centre of Chinese Medicine for Spleen and Stomach, Fuzhou 350003, China.
Evid Based Complement Alternat Med. 2022 Jul 13;2022:7931730. doi: 10.1155/2022/7931730. eCollection 2022.
Functional constipation (FC) is a common condition that would be hard to treat in clinical practice with a prevalence incidence in the population. Pharmacotherapy is a common treatment modality. However, clinical effects are limited and patients continue to suffer from it. In recent years, with the gradual increase in research on gut microbiota, it is understood that dysbiosis of the gut microbiota is importantly associated with the development of constipation. Recent studies have shown that fecal microbiota transplantation (FMT) is an effective method for restoring gut microbiota, as well as being efficacious in the treatment of FC. This mini review explains the characteristics of gut microbiota in FC patients, the mechanism of action of FMT, treatment modalities, current efficacy, and related problems. The purpose is to provide research directions and references for the future applications of FMT in FC.
功能性便秘（FC）是一种常见病症，在临床实践中治疗难度较大，在人群中具有一定的发病率。药物治疗是一种常用的治疗方式。然而，临床效果有限，患者仍深受其苦。近年来，随着对肠道微生物群研究的逐渐增多，人们认识到肠道微生物群失调与便秘的发生密切相关。近期研究表明，粪便微生物群移植（FMT）是恢复肠道微生物群的有效方法，对功能性便秘的治疗也有效果。这篇小型综述阐述了功能性便秘患者肠道微生物群的特征、粪便微生物群移植的作用机制、治疗方式、当前疗效以及相关问题。目的是为粪便微生物群移植在功能性便秘中的未来应用提供研究方向和参考。
