College of Food Science, Fujian Agriculture and Forestry University, 350002 Fuzhou, China.
Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, 350002 Fuzhou, China.
Oxid Med Cell Longev. 2022 Jul 13;2022:3910116. doi: 10.1155/2022/3910116. eCollection 2022.
Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects. Therefore, there is an urgent need to search for safe and natural foods that do not cause adverse effects as alternatives to commercial drugs. In this study, the active substances from , , , and chromium-rich yeast were used to obtain functional formulations (SFFs), and its therapeutic effects on mice with glycolipid metabolism disorder (GLD) were investigated. Results showed that SFFs not only improved glycolipid metabolism and reduced inflammation in mice with GLD but also showed good regenerative effects on the liver, jejunum, and cecum tissues. Moreover, SFFs could inhibit the growth of harmful microbes in the intestine and promote the proliferation of beneficial bacteria, thereby promoting the production of short-chain fatty acids and further regulating GLD. Additionally, SFFs significantly increased the expression of INS, INSR, IRS-1, PI3K, AKT-1, and GLUT-4 genes and significantly decreased that of GSK-3 in the INS/PI3K/GLUT-4 signaling pathway. Therefore, the findings of this study suggest that SFFs can be further developed as a new class of therapeutic agents against GLD.
胰岛素抵抗是 2 型糖尿病发病机制中的主要因素。虽然口服药物二甲双胍 (MH) 被广泛用于降低高血糖，但它与不良反应有关。因此，迫切需要寻找安全和天然的食物，作为商业药物的替代品，而不会引起不良反应。在这项研究中，从 、 、 、和富铬酵母中提取活性物质，获得了功能性配方 (SFF)，并研究了其对糖脂代谢紊乱 (GLD) 小鼠的治疗作用。结果表明，SFF 不仅改善了 GLD 小鼠的糖脂代谢，减轻了炎症，而且对肝脏、空肠和盲肠组织具有良好的再生作用。此外，SFF 可以抑制肠道中有害微生物的生长，促进有益细菌的增殖，从而促进短链脂肪酸的产生，并进一步调节 GLD。此外，SFF 显著增加了 INS、INSR、IRS-1、PI3K、AKT-1 和 GLUT-4 基因的表达，同时显著降低了 INS/PI3K/GLUT-4 信号通路中 GSK-3 的表达。因此，这项研究的结果表明，SFF 可以进一步开发为治疗 GLD 的新型治疗药物。
