在一名胰岛细胞增生患者中，二氮嗪对甲苯磺丁脲诱导的胰岛素释放产生反常增强作用。

Paradoxical enhancement of tolbutamide-induced insulin release by diazoxide in a patient with islet cell hyperplasia.

作者信息

Schikman C H, Chertow B S, Fariss B L

出版信息

Acta Paediatr Scand. 1978 Sep;67(5):671-6. doi: 10.1111/j.1651-2227.1978.tb17822.x.

DOI:10.1111/j.1651-2227.1978.tb17822.x

Abstract

A case of islet cell hyperplasia in a ten year old black male with symptomatic fasting hypoglycemia was documented histopathologically. Provocative studies with glucose, tolbutamide, glucagon, and diazoxide were performed to test the insulin response of hyperplastic islets. The islets responded to glucose, glucagon, and tolbutamide. Diazoxide potentiated the tolbutamide-induced insulin response, and this effect of diazoxide was not blocked by propranolol. In the diagnostic work up of islet cell hyperplasia, dizoxide may paradoxically potentiate tolbutamide-induced insulin release, a finding which may falsely suggest progression of the disease.

摘要

一名患有症状性空腹低血糖症的10岁黑人男性胰岛细胞增生病例经组织病理学证实。进行了葡萄糖、甲苯磺丁脲、胰高血糖素和二氮嗪的激发试验，以测试增生胰岛的胰岛素反应。胰岛对葡萄糖、胰高血糖素和甲苯磺丁脲有反应。二氮嗪增强了甲苯磺丁脲诱导的胰岛素反应，且二氮嗪的这种作用未被普萘洛尔阻断。在胰岛细胞增生的诊断检查中，二氮嗪可能反常地增强甲苯磺丁脲诱导的胰岛素释放，这一发现可能错误地提示疾病进展。