Dramowski Angela, Aucamp Marina, Beales Emily, Bekker Adrie, Cotton Mark Frederic, Fitzgerald Felicity C, Labi Appiah-Korang, Russell Neal, Strysko Jonathan, Whitelaw Andrew, Coffin Susan
Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Infection Prevention and Control Service, Mowbray Maternity Hospital, Cape Town, South Africa.
Front Pediatr. 2022 Jul 7;10:919403. doi: 10.3389/fped.2022.919403. eCollection 2022.
Healthcare-associated infections (HAIs) and antimicrobial-resistant (AMR) infections are leading causes of neonatal morbidity and mortality, contributing to an extended hospital stay and increased healthcare costs. Although the burden and impact of HAI/AMR in resource-limited neonatal units are substantial, there are few HAI/AMR prevention studies in these settings. We reviewed the mechanism of action and evidence supporting HAI/AMR prevention interventions, including care bundles, for hospitalized neonates in low- and middle-income countries (LMIC).
医疗保健相关感染（HAIs）和抗菌药物耐药（AMR）感染是新生儿发病和死亡的主要原因，会导致住院时间延长和医疗保健成本增加。尽管资源有限的新生儿病房中HAI/AMR的负担和影响很大，但在这些环境中进行的HAI/AMR预防研究很少。我们回顾了低收入和中等收入国家（LMIC）住院新生儿HAI/AMR预防干预措施（包括护理集束）的作用机制和证据。
