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发热原因待查、消耗综合征伴骨髓累及:一例麻风病例报告。

Fever of Unknown Origin, Wasting Syndrome and Bone Marrow Involvement: A Leprosy Case Report.

机构信息

National Reference Center for Sanitary Dermatology and Leprosy, Clinics' Hospital, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.

Faculty of Medicine, Federal University of Uberlândia, Uberlândia, Brazil.

出版信息

Front Immunol. 2022 Jul 7;13:916319. doi: 10.3389/fimmu.2022.916319. eCollection 2022.

Abstract

, the etiologic agent of leprosy, is an acid-fast-staining and slow-growing bacilli that infect macrophages and Schwann cells individually or through forming globi. The clinical presentation of leprosy is broad and depends on the host immune response. We report a case of a 42-year-old Brazilian man presenting with fever of unknown origin (FUO), anemia, wasting syndrome, and neuropathy. The diagnosis of lepromatous leprosy was made after an extensive investigation revealed the presence of in the bone marrow. Bone marrow involvement in leprosy is rare and some authors believe the presence of in the bone marrow can act as a reservoir of the disease facilitating future relapses. It is important to investigate bone marrow involvement in leprosy, especially when the patient presents with cytopenias and positive epidemiologic history.

摘要

麻风分枝杆菌是麻风病的病原体,为一种抗酸染色阳性、生长缓慢的杆菌,可单独或通过形成 globi 感染巨噬细胞和施万细胞。麻风病的临床表现广泛,取决于宿主的免疫反应。我们报告了一例 42 岁巴西男性,表现为不明原因发热(FUO)、贫血、消瘦综合征和神经病。在广泛的检查后发现骨髓中存在 ,诊断为瘤型麻风。麻风病骨髓受累罕见,一些作者认为骨髓中 存在可以作为疾病的储库,促进未来的复发。当患者出现细胞减少症和阳性流行病学史时,调查麻风病骨髓受累情况非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0134/9300819/7b4c2d22d593/fimmu-13-916319-g001.jpg

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