Peces R, Riera J R, Arboleya L R, López-Larrea C, Alvarez J
Nephron. 1987;45(4):316-20. doi: 10.1159/000184171.
A 51-year-old woman with advanced rheumatoid arthritis developed a Goodpasture's syndrome during treatment with penicillamine and carbimazole. Circulating antiglomerular basement membrane antibodies (anti-GBM) were present. Renal biopsy showed focal necrotizing glomerulonephritis with crescents, and HLA typing showed the presence of DR3 and DR4. The patient responded dramatically to pulse methylprednisolone and cyclophosphamide, with both clinical remission and disappearance of anti-GBM antibodies.
一名51岁患有晚期类风湿性关节炎的女性在使用青霉胺和卡比马唑治疗期间发生了肺出血肾炎综合征。存在循环抗肾小球基底膜抗体（抗GBM）。肾活检显示局灶性坏死性新月体性肾小球肾炎，HLA分型显示存在DR3和DR4。患者对甲泼尼龙冲击疗法和环磷酰胺反应显著，临床缓解且抗GBM抗体消失。
