Cambria S, Gambardella G, Cardia E, Cambria M
Neurochirurgie. 1986;32(4):339-42.
When the original idea was conceived 8 years ago to develop a surgical technique for the treatment of fetal hydrocephalus, the pathway towards prenatal surgery for this affection was totally unexplored. The operation appeared to be feasible because of the possibility of a ventriculo-amniotic shunt. The most important steps in our experimental studies in the ewe were creation of a fetal hydrocephalus by injection of a suspension of kaolin powder into cisterna magna; the treatment of the hydrocephalus by a mini-ventriculo-amniotic shunt, by cutting the cardiac end of a low pressure Pudenz pediatric catheter. Lambs were delivered by Cesarean two weeks before end of gestation. Coronal sections of brains of control and treated lambs showed reduction in hydrocephalus in the latter. These findings were the basis for the application of the method to treatment of human fetal hydrocephalus.
8年前，当最初构思开发一种治疗胎儿脑积水的外科技术时，针对这种病症的产前手术途径完全未被探索。由于存在脑室-羊膜分流的可能性，该手术似乎是可行的。我们在母羊身上进行的实验研究中最重要的步骤包括：通过向小脑延髓池注射高岭土粉末悬浮液来制造胎儿脑积水；通过切断低压普登斯小儿导管的心端，采用微型脑室-羊膜分流术治疗脑积水。在妊娠结束前两周通过剖宫产分娩羔羊。对照羔羊和接受治疗的羔羊的脑冠状切片显示，后者的脑积水有所减轻。这些发现是将该方法应用于人类胎儿脑积水治疗的基础。
