Bournerias F, Monnier N, Dufier J L, Réveillaud R J
Nephrologie. 1987;8(1):27-9.
Severe and persistent visual loss with retinitis pigmentosa occurred in a hemodialyzed patient, treated with desferrioxamine (DFO) for aluminium intoxication, with a total DFO dose of 18 g given over 9 weeks. Cases reported since 1983 are reviewed, and hypothesis and risk factors for DFO toxicity are discussed. Caution should be exercised in using DFO in hemodialyzed patients.
一名接受血液透析的患者因铝中毒接受去铁胺(DFO)治疗,9周内DFO总剂量达18克,出现了伴有色素性视网膜炎的严重且持续性视力丧失。对1983年以来报告的病例进行了回顾,并讨论了DFO毒性的假说和危险因素。在血液透析患者中使用DFO时应谨慎。