Nuutinen Mikko, Lyly Annina, Virkkula Paula, Hytönen Maija, Saarentaus Elmo, Mäkitie Antti, Palotie Aarno, Torkki Paulus, Haukka Jari, Toppila-Salmi Sanna
Haartman Institute University of Helsinki Helsinki Finland.
Skin and Allergy Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland.
Clin Transl Allergy. 2022 Jul 21;12(7):e12181. doi: 10.1002/clt2.12181. eCollection 2022 Jul.
The aim was to evaluate the relative proportion of Non-steroidal anti-inflammatory drug exacerbated respiratory disease (NERD) and other comorbidities, and their impact on the burden of outpatient visits due to allergic rhinitis (AR), non-allergic rhinitis (NAR), acute rhinosinusitis (ARS), and chronic rhinosinusitis with nasal polyps (CRSwNP) and without (CRSsNP).
We used hospital registry data of a random sample of 5080 rhinitis/rhinosinusitis patients diagnosed during 2005-2019. International Statistical Classification of Diseases and Related Health Problems (ICD10) diagnoses, visits, and other factors were collected from electronic health records by using information extraction and data processing methods. Cox's proportional hazards model was used for modeling the time to the next outpatient visit.
The mean (±standard deviation) age of the population was 33.6 (±20.7) years and 56.1% were female. The relative proportion of AR, NAR, ARS, CRSsNP and CRSwNP, were 33.5%, 27.5%, 27.2%, 20.7%, and 10.9%, respectively. The most common other comorbidities were asthma (44.4%), other chronic respiratory diseases (38.5%), musculoskeletal diseases (38.4%), and cardiovascular diseases (35.7%). Non-steroidal anti-inflammatory drug exacerbated respiratory disease existed in 3.9% of all patients, and 17.7% of the CRSwNP group. The relative proportion of subjects having 1, 2, 3 and ≥ 4 other diseases were 18.0%, 17.6%, 17.0%, 37.0%, respectively. All diseases except AR, ARS, and mouth breathing, were associated with a high frequency of outpatient visits.
Our results revealed a high relative proportion of NERD and other comorbidities, which affect the burden of outpatient visits and hence confirm the socioeconomic impact of upper airway diseases.
目的是评估非甾体抗炎药加重的呼吸道疾病（NERD）和其他合并症的相对比例，以及它们对因过敏性鼻炎（AR）、非过敏性鼻炎（NAR）、急性鼻-鼻窦炎（ARS）、伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）和不伴有鼻息肉的慢性鼻-鼻窦炎（CRSsNP）而进行门诊就诊负担的影响。
我们使用了2005年至2019年期间诊断的5080例鼻炎/鼻-鼻窦炎患者的随机样本的医院登记数据。通过信息提取和数据处理方法从电子健康记录中收集国际疾病分类及相关健康问题（ICD10）诊断、就诊情况及其他因素。采用Cox比例风险模型对下次门诊就诊时间进行建模。
研究人群的平均（±标准差）年龄为33.6（±20.7）岁，56.1%为女性。AR、NAR、ARS、CRSsNP和CRSwNP的相对比例分别为33.5%、27.5%、27.2%、20.7%和10.9%。最常见的其他合并症为哮喘（44.4%）、其他慢性呼吸道疾病（38.5%）、肌肉骨骼疾病（38.4%）和心血管疾病（35.7%）。所有患者中3.9%存在非甾体抗炎药加重的呼吸道疾病，CRSwNP组中为17.7%。患有1种、2种、3种及≥4种其他疾病的受试者的相对比例分别为18.0%、17.6%、17.0%、37.0%。除AR、ARS和口呼吸外，所有疾病均与门诊就诊频率较高相关。
我们的结果显示NERD和其他合并症的相对比例较高，这影响了门诊就诊负担，从而证实了上呼吸道疾病的社会经济影响。
