Nsengimana Bernard, Khan Faiz Ali, Awan Usman Ayub, Wang Dandan, Fang Na, Wei Wenqiang, Zhang Weijuan, Ji Shaoping
Laboratory of Cell Signal Transduction, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
School of Life Sciences, Henan University, Kaifeng, China.
Front Oncol. 2022 Jul 8;12:912282. doi: 10.3389/fonc.2022.912282. eCollection 2022.
Pseudogenes have been considered as non-functional genes. However, peptides and long non-coding RNAs produced by pseudogenes are expressed in different tumors. Moreover, the dysregulation of pseudogenes is associated with cancer, and their expressions are higher in tumors compared to normal tissues. Recent studies show that pseudogenes can influence the liquid phase condensates formation. Liquid phase separation involves regulating different epigenetic stages, including transcription, chromatin organization, 3D DNA structure, splicing, and post-transcription modifications like mA. Several membrane-less organelles, formed through the liquid phase separate, are also involved in the epigenetic regulation, and their defects are associated with cancer development. However, the association between pseudogenes and liquid phase separation remains unrevealed. The current study sought to investigate the relationship between pseudogenes and liquid phase separation in cancer development, as well as their therapeutic implications.
假基因一直被认为是无功能的基因。然而，假基因产生的肽和长链非编码RNA在不同肿瘤中均有表达。此外，假基因的失调与癌症相关，并且它们在肿瘤中的表达高于正常组织。最近的研究表明，假基因可影响液相凝聚物的形成。液相分离涉及调控不同的表观遗传阶段，包括转录、染色质组织、三维DNA结构、剪接以及诸如mA等转录后修饰。通过液相分离形成的几种无膜细胞器也参与表观遗传调控，并且它们的缺陷与癌症发展相关。然而，假基因与液相分离之间的关联仍未明确。本研究旨在探讨假基因与液相分离在癌症发展中的关系及其治疗意义。
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