van Dijk Suzanne E, Lak Jessie, Drenth Nadieh, Hafkemeijer Anne, Rombouts Serge A R B, van der Grond Jeroen, van Rooden Sanneke
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Institute of Psychology, Leiden University, Leiden, The Netherlands.
J Magn Reson Imaging. 2023 Mar;57(3):909-915. doi: 10.1002/jmri.28362. Epub 2022 Jul 25.
Decreased cerebrovascular reactivity, measured as changes in blood-oxygen-level-dependent (BOLD) signal, is a potential new cerebral amyloid angiopathy (CAA) severity marker. Before clinical application, the effect of aging on BOLD parameters, and reproducibility and test-retest reliability of these parameters should be assessed.
Assess the effect of healthy aging on cerebrovascular reactivity (BOLD amplitude, time to peak, and time to baseline). And determine reproducibility and test-retest reliability of these parameters.
Prospective-observational.
Eighty-six healthy adults (mean age 56 years, 55% female), 10 presymptomatic D-CAA mutation carriers (mean age 34 years, 70% female), and 10 symptomatic D-CAA mutation carriers (mean age 54 years, 70% female).
FIELD STRENGTH/SEQUENCE: 3-T, three-dimensional (3D) T1-weighted MRI and gradient echo BOLD fMRI.
To assess test-retest reliability of BOLD parameters, i.e. BOLD amplitude, time to peak, and time to baseline, BOLD fMRI scans were repeated three times immediately after each other, in both controls and mutation carriers. To assess reproducibility, BOLD fMRI scans were repeated with a 3-week interval for each subject.
Linear regression analyses and two-way mixed absolute agreement intra-class correlation approach.
Healthy aging was associated with decreased BOLD amplitude (β = -0.711) and prolonged time to baseline (β = 0.236) in the visual cortex after visual stimulation Reproducibility of BOLD amplitude was excellent (ICC 0.940) in the subgroup of healthy adults. Test-retest reliability for BOLD amplitude was excellent in healthy adults (ICC 0.856-0.910) and presymptomatic D-CAA mutation carriers (ICC 0.959-0.981). In symptomatic D-CAA mutation carriers, test-retest reliability was poor for all parameters (ICCs < 0.5).
Healthy aging is associated with decreased cerebrovascular reactivity, measured by changes in BOLD response to visual stimulation. The BOLD amplitude appears to be a robust measurement in healthy adults and presymptomatic D-CAA mutation carriers, but not in symptomatic D-CAA mutation carriers.
以血氧水平依赖（BOLD）信号变化来衡量的脑血管反应性降低是一种潜在的新型脑淀粉样血管病（CAA）严重程度标志物。在临床应用之前，应评估衰老对BOLD参数的影响以及这些参数的可重复性和重测可靠性。
评估健康衰老对脑血管反应性（BOLD幅度、达峰时间和恢复到基线时间）的影响，并确定这些参数的可重复性和重测可靠性。
前瞻性观察研究。
86名健康成年人（平均年龄56岁，55%为女性）、10名症状前D-CAA突变携带者（平均年龄34岁，70%为女性）和10名症状性D-CAA突变携带者（平均年龄54岁，70%为女性）。
场强/序列：3-T，三维（3D）T1加权MRI和梯度回波BOLD功能磁共振成像。
为评估BOLD参数（即BOLD幅度、达峰时间和恢复到基线时间）的重测可靠性，在对照组和突变携带者中，BOLD功能磁共振成像扫描在彼此之后立即重复三次。为评估可重复性，对每个受试者间隔3周重复进行BOLD功能磁共振成像扫描。
线性回归分析和双向混合绝对一致性组内相关方法。
在视觉刺激后，健康衰老与视觉皮层中BOLD幅度降低（β = -0.711）和恢复到基线时间延长（β = 0.236）相关。在健康成年人亚组中，BOLD幅度的可重复性极佳（组内相关系数ICC为0.940）。在健康成年人（ICC为0.856 - 0.910）和症状前D-CAA突变携带者（ICC为0.959 - 0.981）中，BOLD幅度的重测可靠性极佳。在症状性D-CAA突变携带者中，所有参数的重测可靠性均较差（组内相关系数<0.5）。
健康衰老与视觉刺激诱发的BOLD反应变化所测量的脑血管反应性降低相关。BOLD幅度在健康成年人和症状前D-CAA突变携带者中似乎是一种可靠的测量指标，但在症状性D-CAA突变携带者中并非如此。
