College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China.
Dalton Trans. 2022 Aug 9;51(31):11868-11875. doi: 10.1039/d2dt01841a.
A green and sustainable electrochemical hydroboration of carbonyl compounds with HBpin has been reported for the first time. Under catalyst-free and additive-free mild reaction conditions the corresponding boronic esters were obtained in excellent yields the simple electrochemical hydroboration of various aldehydes and ketones with HBpin at room temperature. The scale-up reaction demonstrated potential practical applications. A plausible reaction mechanism was proposed based on the corresponding deuterium-labelling, radical inhibition and cyclic voltammetry experiments.
首次报道了一种绿色可持续的羰基化合物与 HBpin 的电催化硼氢化反应。在无催化剂和添加剂的温和反应条件下，各种醛酮与 HBpin 在室温下发生简单的电催化硼氢化反应，以极好的收率得到相应的硼酸酯。放大反应显示出潜在的实际应用。基于相应的氘标记、自由基抑制和循环伏安实验，提出了一种合理的反应机理。
