Emerg Infect Dis. 2022 Aug;28(8):1606-1614. doi: 10.3201/eid2808.212440.
After switching from 13-valent to 10-valent pneumococcal conjugate vaccine (PCV10) (2015-2016) for children in Belgium, we observed rapid reemergence of serotype 19A invasive pneumococcal disease (IPD). Whole-genome sequencing of 166 serotype 19A IPD isolates from children (n = 54) and older adults (n = 56) and carriage isolates from healthy children (n = 56) collected after the vaccine switch (2017-2018) showed 24 sequence types (STs). ST416 (global pneumococcal sequence cluster [GPSC] 4) and ST994 (GPSC146) accounted for 75.9% of IPD strains from children and 65.7% of IPD (children and older adults) and carriage isolates in the PCV10 period (2017-2018). These STs differed from predominant 19A IPD STs after introduction of PCV7 (2011) in Belgium (ST193 [GPSC11] and ST276 [GPSC10]), which indicates that prediction of emerging strains cannot be based solely on historical emerging strains. Despite their susceptible antimicrobial drug profiles, these clones spread in carriage and IPD during PCV10 use.
在比利时将儿童用 13 价肺炎球菌结合疫苗（PCV10）（2015-2016 年）切换为 10 价疫苗（PCV10）后，我们观察到血清型 19A 侵袭性肺炎球菌病（IPD）迅速重新出现。对 2017-2018 年疫苗切换后（2017-2018 年）从儿童（n=54）和老年人（n=56）中分离的 166 株血清型 19A IPD 分离株和携带分离株（n=56）进行全基因组测序，显示 24 种序列型（ST）。ST416（全球肺炎球菌序列簇[GPSC]4）和 ST994（GPSC146）分别占儿童 IPD 菌株的 75.9%和儿童和老年人 IPD（2017-2018 年 PCV10 期间）和携带分离株的 65.7%。这些 ST 与比利时引入 PCV7（2011 年）后主要的 19A IPD ST 不同（ST193[GPSC11]和 ST276[GPSC10]），这表明预测新出现的菌株不能仅基于历史上出现的菌株。尽管这些克隆对抗菌药物敏感，但它们在 PCV10 使用期间在携带和 IPD 中传播。
