Caballero Francisco Félix, Lana Alberto, Struijk Ellen A, Arias-Fernández Lucía, Yévenes-Briones Humberto, Cárdenas-Valladolid Juan, Salinero-Fort Miguel Ángel, Banegas José R, Rodríguez-Artalejo Fernando, Lopez-Garcia Esther
Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid and CIBER of Epidemiology and Public Health, Madrid, Spain.
Department of Medicine, Universidad de Oviedo/ISPA, Oviedo, Spain.
J Gerontol A Biol Sci Med Sci. 2023 Mar 30;78(4):637-644. doi: 10.1093/gerona/glac144.
Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of 9 amino acids, including branched-chain and aromatic amino acids, and multimorbidity.
This research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain that comprises noninstitutionalized adults older than 65. Blood samples were extracted at baseline and after a follow-up period of 2 years for a total of 1 488 subjects. Participants' information was linked with electronic health records. Chronic diseases were grouped into a list of 60 mutually exclusive conditions. A quantitative measure of multimorbidity, weighting morbidities by their regression coefficients on physical functioning, was employed and ranged from 0 to 100. Generalized estimating equation models were used to explore the relationship between plasma amino acids and multimorbidity, adjusting for sociodemographics, socioeconomic status, and lifestyle behaviors.
The mean age of participants at baseline was 73.6 (SD = 4.2) years, 49.6% were women. Higher concentrations of glutamine (coef. per mmol/l [95% confidence interval] = 10.1 [3.7, 16.6]), isoleucine (50.3 [21.7, 78.9]), and valine (15.5 [3.1, 28.0]) were significantly associated with higher multimorbidity scores, after adjusting for potential confounders. Body mass index could have influenced the relationship between isoleucine and multimorbidity (p = .016).
Amino acids could play a role in regulating aging-related diseases. Glutamine and branched-chain amino acids as isoleucine and valine are prospectively associated and could serve as risk markers for multimorbidity in older adults.
一些氨基酸与衰老相关疾病及身体功能受损风险有关。本研究旨在评估包括支链氨基酸和芳香族氨基酸在内的9种氨基酸的血浆浓度与多种疾病并存之间的关联。
本研究使用了来自西班牙基于人群的队列研究Seniors-ENRICA 2的纵向数据，该队列包括65岁以上的非机构化成年人。共1488名受试者在基线时和随访2年后采集了血样。参与者的信息与电子健康记录相关联。慢性疾病被归类为60种相互排斥的疾病清单。采用一种多种疾病并存的定量测量方法，根据疾病对身体功能的回归系数对疾病进行加权，范围为0至100。使用广义估计方程模型来探讨血浆氨基酸与多种疾病并存之间的关系，并对社会人口统计学、社会经济地位和生活方式行为进行了调整。
参与者在基线时的平均年龄为73.6（标准差 = 4.2）岁，49.6%为女性。在调整潜在混杂因素后，较高浓度的谷氨酰胺（每毫摩尔/升的系数[95%置信区间] = 10.1 [3.7, 16.6]）、异亮氨酸（50.3 [21.7, 78.9]）和缬氨酸（15.5 [3.1, 28.0]）与较高的多种疾病并存得分显著相关。体重指数可能影响了异亮氨酸与多种疾病并存之间的关系（p = 0.016）。
氨基酸可能在调节衰老相关疾病中发挥作用。谷氨酰胺以及支链氨基酸如异亮氨酸和缬氨酸与多种疾病并存存在前瞻性关联，可作为老年人多种疾病并存的风险标志物。
