Department of Gastrointestinal Surgery & Solid Organ Transplant, Amrita Institute of Medical Sciences & Research Centre, Amrita University, Kochi, Kerala, India.
Department of Biostatistics, Regional Cancer Centre, Trivandrum, Kerala, India.
Clin Transplant. 2022 Sep;36(9):e14775. doi: 10.1111/ctr.14775. Epub 2022 Aug 10.
Robotic right live donor hepatectomy (r-LDRH) has been reported with reduced morbidity compared to open donor right hepatectomy (o-LDRH) in few recent series. Nevertheless, its routine use is debated. We present a large series comparing pure r-LDRH with o-LDRH. Consecutive r-LDRH performed from June 2018 to June 2020 (n = 102) were compared with consecutive donors undergoing o-LDRH (n = 152) from February 2016 to February 2018, a period when r-LDRH was not available at this center. Propensity score matched (PSM) analysis of 89 case-control pairs was additionally performed. Primary endpoints were length of high dependency unit (HDU) and hospital stay and Clavien-Dindo graded complications among donors. Although r-LDRH took longer to perform (540 vs. 462 min, P < .001), the postoperative peak transaminases levels (P < .001), the length of HDU (3 vs. 4 days, P < .001), and hospital stay (8 vs. 9 days, P < .001) were lower in in donors undergoing r-LDRH. Clavien-Dindo graded complications were similar (16.67% in r-LDRH and 13.16% in o-LDRH). The rates of early allograft dysfunction (1.6% vs. 3.3%), bile leak (14.7% vs. 10.7%), and 1-year mortality (13.7% vs. 11.8%) were comparable between r-LDRH and o-LDRH recipients. PSM analysis yielded similar results between the groups. These data support the safety and feasibility of r-LDRH in select donors.
机器人辅助右半肝活体供肝切除术(r-LDRH)与开放右半肝活体供肝切除术(o-LDRH)相比,在少数近期系列中报告的发病率较低。然而,其常规应用仍存在争议。我们报告了一项比较纯 r-LDRH 与 o-LDRH 的大型系列研究。从 2018 年 6 月至 2020 年 6 月连续进行 r-LDRH(n=102)的患者与 2016 年 2 月至 2018 年 2 月连续接受 o-LDRH 的供者(n=152)进行比较,在此期间该中心不提供 r-LDRH。另外还对 89 例病例对照对进行了倾向评分匹配(PSM)分析。供者的主要终点是高依赖单位(HDU)和住院时间以及 Clavien-Dindo 分级并发症。尽管 r-LDRH 手术时间更长(540 分钟 vs. 462 分钟,P<.001),但术后转氨酶峰值(P<.001)、HDU 时间(3 天 vs. 4 天,P<.001)和住院时间(8 天 vs. 9 天,P<.001)较低。r-LDRH 供者的 Clavien-Dindo 分级并发症相似(r-LDRH 为 16.67%,o-LDRH 为 13.16%)。早期移植物功能障碍(1.6% vs. 3.3%)、胆漏(14.7% vs. 10.7%)和 1 年死亡率(13.7% vs. 11.8%)在 r-LDRH 和 o-LDRH 受者之间相似。PSM 分析两组间结果相似。这些数据支持 r-LDRH 在选择供者中的安全性和可行性。