Centre for Chronobiology, University of Basel, Basel, Switzerland.
Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.
Acta Psychiatr Scand. 2022 Oct;146(4):350-356. doi: 10.1111/acps.13482. Epub 2022 Aug 3.
Perinatal depression (PND) is a severe complication of pregnancy, affecting both mothers and newborns. Bright light therapy (BLT) has only been tested in a few studies for treating either antenatal or postnatal depression. We conducted a pilot trial to investigate the efficacy and safety of BLT for PND occurring at any time across the perinatal period.
A single-blind RCT was carried out in women with an EPDS >12 from the 2nd gestational trimester until 9 months postpartum. Participants received either 30-minutes morning BLT (10'000 lux) or dim red light (DRL, 19 lux) for 6 weeks.
Twenty-two women were randomised to BLT (n = 11) or DRL (n = 11). Among those receiving BLT, 73% achieved remission (improvement ≥50%, EPDS score ≤ 12), in contrast to 27% in the DRL group (p = 0.04). A significant influence of time on EPDS score and group-time interaction emerged, with a greater reduction in the BLT-group across the follow-up period. No women in either group reported major side effects.
Morning BLT induced a significant remission from PND as compared to DRL and this effect was maintained across the perinatal period. BLT showed an excellent safety profile and was well-tolerated, thus representing a valid therapeutic strategy in this vulnerable perinatal population.
围产期抑郁症（PND）是一种严重的妊娠并发症，影响母亲和新生儿。光照疗法（BLT）仅在少数研究中针对产前或产后抑郁症进行了测试。我们进行了一项试点试验，以调查 BLT 治疗围产期任何时间发生的 PND 的疗效和安全性。
一项单盲 RCT 在 EPDS>12 的孕妇中进行，从妊娠第 2 个妊娠期直至产后 9 个月。参与者接受每天 30 分钟的早晨 BLT（10,000 勒克斯）或昏暗的红光（DRL，19 勒克斯）治疗 6 周。
22 名女性被随机分配到 BLT 组（n=11）或 DRL 组（n=11）。在接受 BLT 的患者中，73%达到缓解（改善≥50%，EPDS 评分≤12），而 DRL 组为 27%（p=0.04）。EPDS 评分和组间时间交互作用的时间有显著影响，BLT 组在整个随访期间的降幅更大。两组均无女性报告主要副作用。
与 DRL 相比，早晨 BLT 可显著缓解 PND，且这种效果在围产期持续存在。BLT 表现出极好的安全性和耐受性，因此代表了这一脆弱围产期人群的有效治疗策略。
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