Department of Food and Nutrition Science, Koran Women's Junior College, 1 Chome-2-1Yokote, Minami-ku, Fukuoka, 811-1311, Japan.
Arch Microbiol. 2022 Jul 25;204(8):520. doi: 10.1007/s00203-022-03142-y.
Terpenoids are natural compounds originating from five-carbon isoprene units. Over 60,000 terpenoid structures have been identified, and they contribute to the flavor, color, growth, and development of plants. There are several reports on various physiological activities of terpenoids, such as antioxidative and anticancer activities. This study revealed that combinations of terpenoids have activities against a spectrum of bacteria. The combination of carvacrol and thymol has bacteriostatic and bactericidal activities. Four terpenoids (carvacrol, thymol, eugenol, and nootkatone) exhibited bacteriostatic and bactericidal activities when used at low concentrations for 5‒10 min. The most effective bactericidal activity was observed for gram-negative bacteria. A very weak bactericidal activity was observed against Staphylococcus aureus and Enterococcus faecalis. This study revealed the antibacterial potential of different combinations of terpenoids against several bacteria that were tested. Thus, new candidates for the development of antibacterial medicines are reported here for the effective treatment of infectious bacterial diseases.
萜类化合物是源自五碳异戊二烯单元的天然化合物。已经鉴定出超过 60,000 种萜类化合物结构，它们有助于植物的风味、颜色、生长和发育。有多项报告表明萜类化合物具有多种生理活性，如抗氧化和抗癌活性。本研究表明萜类化合物的组合对多种细菌具有活性。香芹酚和百里香酚的组合具有抑菌和杀菌活性。四种萜类化合物（香芹酚、百里香酚、丁香酚和诺卡酮）在 5-10 分钟的低浓度下表现出抑菌和杀菌活性。杀菌活性对革兰氏阴性菌最为有效。对金黄色葡萄球菌和粪肠球菌的杀菌活性较弱。本研究揭示了不同萜类化合物组合对几种测试细菌的抗菌潜力。因此，本文报道了一些新的候选抗菌药物，用于有效治疗传染性细菌性疾病。
