Kang Yun, Lu Jin-Liang, Zhang Zhi, Liang Ying-Kang, Ma Ai-Jun, Peng Jin-Bao
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, People's Republic of China.
J Org Chem. 2023 Apr 21;88(8):5097-5107. doi: 10.1021/acs.joc.2c01253. Epub 2022 Jul 25.
A palladium-catalyzed intramolecular Heck/aminocarbonylation of alkene-tethered iodobenzenes with nitro compounds has been developed for the synthesis of carbamoyl-substituted benzoheterocycles. Using Mo(CO) as a solid CO source, no external reductant or additives were needed in this procedure. Both nitroarenes and nitroalkanes were well tolerated. A range of carbamoyl-substituted dihydrobenzofurans and indolines were prepared in moderate to high yields.
已开发出一种钯催化的、将烯烃连接的碘苯与硝基化合物进行分子内Heck/氨甲酰化反应的方法，用于合成氨甲酰基取代的苯并杂环化合物。使用Mo(CO)作为固体CO源，该过程无需外部还原剂或添加剂。硝基芳烃和硝基烷烃都具有良好的耐受性。一系列氨甲酰基取代的二氢苯并呋喃和吲哚啉以中等至高收率制备出来。
