Department of Medical Physics, BC Cancer, Vancouver, BC V5Z 4E6, Canada.
Department of Surgery, Division of Radiation Oncology and Developmental Radiotherapeutics, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
Curr Oncol. 2022 Jul 7;29(7):4734-4747. doi: 10.3390/curroncol29070376.
There has been an increasing interest in patient-reported outcome (PRO) measures in both the clinical and research settings to improve the quality of life among patients and to identify when clinical intervention may be needed. The primary purpose of this prospective study was to validate an acute breast skin toxicity PRO measure across a broad sample of patient body types undergoing radiation therapy. Between August 2018 and September 2019, 134 women undergoing adjuvant breast radiotherapy (RT) consented to completing serial PRO measures both during and post-RT treatment and to having their skin assessed by trained trial radiation therapists. There was high patient compliance, with 124 patients (92.5%) returning to the clinic post-RT for at least one staff skin assessment. Rates of moist desquamation (MD) in the infra-mammary fold (IMF) by PRO were compared with skin assessments completed by trial radiation therapists. There was high sensitivity (86.5%) and good specificity (79.4%) between PRO and staff-reported presence of MD in the IMF, and there was a moderate correlation between the peak severity of the MD reported by PRO and assessed by staff (rho = 0.61, p < 0.001). This prospective study validates a new PRO measure to monitor the presence of MD in the IMF among women receiving breast RT.
人们对患者报告的结局（PRO）测量在临床和研究环境中的应用越来越感兴趣，以提高患者的生活质量，并确定何时需要临床干预。本前瞻性研究的主要目的是验证一种新的急性乳房皮肤毒性 PRO 测量方法，该方法适用于接受放射治疗的广泛体型的患者。在 2018 年 8 月至 2019 年 9 月期间，134 名接受辅助乳房放疗（RT）的女性同意在 RT 治疗期间和治疗后连续完成 PRO 测量，并由经过培训的试验放射治疗师对其皮肤进行评估。患者的依从性很高，有 124 名患者（92.5%）在 RT 后至少返回诊所进行一次工作人员皮肤评估。PRO 评估的乳房下皱襞（IMF）湿性脱皮（MD）发生率与试验放射治疗师完成的皮肤评估进行了比较。PRO 与工作人员报告的 IMF 中 MD 存在之间具有高灵敏度（86.5%）和良好的特异性（79.4%），并且 PRO 报告的 MD 严重程度峰值与工作人员评估的结果之间存在中度相关性（rho=0.61，p<0.001）。这项前瞻性研究验证了一种新的 PRO 测量方法，用于监测接受乳房 RT 的女性 IMF 中 MD 的存在。
