Recovery of cortical acetylcholine output after ganglioside treatment in rats with lesion of the nucleus basalis.
作者信息
Florian A, Casamenti F, Pepeu G
出版信息
Neurosci Lett. 1987 Apr 10;75(3):313-6. doi: 10.1016/0304-3940(87)90541-6.
PMID:3587737
Abstract
The changes in acetylcholine release from the cerebral cortex induced by a unilateral electrolytic lesion of the nucleus basalis and by a treatment with GM1 monosialoganglioside (30 mg/kg i.p. for 20 days) were investigated. Acetylcholine release was measured using the cortical cup technique in rats transected at midpontine level. In the lesioned rats treated with saline an ipsilateral 38% decrease in acetylcholine release was observed. GM1 treatment prevented the decrease and brought about a 30% contralateral increase. These results indicate that GM1 induces a functional recovery of the cholinergic neurons ascending to the cortex.
摘要
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