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由皮质损伤引起的大鼠基底核逆行性变化可被外源性神经节苷脂GM1阻止。

Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1.

作者信息

Cuello A C, Stephens P H, Tagari P C, Sofroniew M V, Pearson R C

出版信息

Brain Res. 1986 Jun 25;376(2):373-7. doi: 10.1016/0006-8993(86)90202-7.

DOI:10.1016/0006-8993(86)90202-7
PMID:3730841
Abstract

In rats with extensive unilateral cortical damage, retrograde effects upon the cholinergic cells of the basal nucleus were observed. Cells of the basal nucleus stained immunocytochemically for choline acetyltransferase were shrunken and choline acetyltransferase enzymatic activity in that region was reduced. Both these effects could be prevented by the administration of the ganglioside GM1.

摘要

在患有广泛性单侧皮质损伤的大鼠中，观察到对基底核胆碱能细胞的逆行性影响。用免疫细胞化学方法对胆碱乙酰转移酶染色的基底核细胞萎缩，且该区域的胆碱乙酰转移酶活性降低。给予神经节苷脂GM1可预防这两种效应。

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