Yang Runmiao, Jin Wei, Huang Chingcheng, Liu Yuhai
Department of Material Engineering, Jiangsu University of Technology, Changzhou 213001, China.
PARSD Biomedical Material Research Center, Changzhou 213001, China.
Gels. 2022 Jul 1;8(7):414. doi: 10.3390/gels8070414.
A new azobenzene-based symmetric amphiphile was synthesized and characterized using H NMR spectroscopy. Its self-assembly behavior as well as photo-responsive behavior in its solution and gel states were investigated. Such a compound can self-assemble into fiber mesophases in water solvent. After irradiation of the gels with UV light, the isomer of the compound rapidly photoisomerized to the isomer, which resulted in a rapid destruction of the gel. High temperature also caused a rapid drop in viscosity. To verify the antimicrobial activity of the hydrogel, live and death assays of human fibroblasts L929 properties were used for in vitro cell viability studies. The compound was converted to the terminal tertiary amine in a quaternary ammonium salt molecule by using hydrochloric acid. This azobenzene quaternary ammonium salt has a relatively better antimicrobial effect biocidal activity that was demonstrated when challenged against Escherichia coli on in vitro conditions.
合成了一种新型基于偶氮苯的对称两亲物，并利用核磁共振氢谱对其进行了表征。研究了其在溶液和凝胶状态下的自组装行为以及光响应行为。这种化合物在水溶剂中可自组装成纤维中间相。用紫外光照射凝胶后，该化合物的异构体迅速光异构化为异构体，导致凝胶迅速破坏。高温也导致粘度迅速下降。为了验证水凝胶的抗菌活性，使用人成纤维细胞L929的活死检测进行体外细胞活力研究。通过使用盐酸将该化合物转化为季铵盐分子中的末端叔胺。这种偶氮苯季铵盐具有相对较好的抗菌效果，在体外条件下对大肠杆菌进行挑战时表现出杀菌活性。
