College of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Department of Chemical, Biomolecular, and Corrosion Engineering, College of Engineering and Polymer Science, The University of Akron, Ohio 44325, USA.
J Mater Chem B. 2022 Apr 20;10(16):3039-3047. doi: 10.1039/d2tb00206j.
Bacterial infections from biomedical devices pose a great threat to the health of humans and thus place a heavy burden on society. Therefore, developing efficient antibacterial surfaces has attracted much attention. However, it is a challenge to identify or develop a combination that efficiently integrates multiple functions topological tailoring and on-demand function-switch non-contact and noninvasive stimuli. To resolve this issue, a highly hydrophilic comb polymer brush was constructed here based on supramolecular host-guest recognition. Azobenzene (azo)-modified antifouling and antibacterial polymers were incorporated into cyclodextrin (CD)-modified antifouling polymer brushes grafted on the surface. The surface thus obtained possessed excellent antifouling performance with a low bacterial density of ∼6.25 × 10 cells per cm after 48 h and exhibited a high efficiency of ∼88.2% for killing bacteria. Besides, irradiation with UV light resulted in the desorption of the azo-polymers and a release of ∼85.1% attached bacteria. Irradiating visible light led to the re-adsorption of azo-polymers, which regenerated the fresh surface; the process could be repeated for at least three cycles, and the surface still maintained low bacterial attachments with a cell density of ∼7.10 × 10 cells per cm, high sterilization efficiency of ∼93.8%, and a bacteria release rate of ∼83.1% in the 3rd cycle. The photo-switchable antibacterial surface presented in this research will provide new insights into the development of smart biomedical surfaces.
生物医学设备引发的细菌感染对人类健康构成了巨大威胁，因此给社会带来了沉重的负担。因此，开发高效的抗菌表面引起了广泛关注。然而，识别或开发一种能够有效整合多种功能（拓扑剪裁和按需功能切换、非接触和非侵入性刺激）的组合仍然是一个挑战。为了解决这个问题，我们基于超分子主客体识别构建了一种高度亲水的梳状聚合物刷。将偶氮苯（azo）改性的抗污和抗菌聚合物掺入到接枝在表面上的环糊精（CD）改性的抗污聚合物刷中。所得表面具有出色的抗污性能，在 48 小时后细菌密度约为 6.25×10 个细胞/平方厘米，杀菌效率高达约 88.2%。此外，用紫外光照射会导致偶氮聚合物解吸，并释放约 85.1%的附着细菌。用可见光照射会导致偶氮聚合物重新吸附，从而使新鲜表面再生；该过程至少可以重复三个循环，表面仍保持低细菌附着，细胞密度约为 7.10×10 个细胞/平方厘米，第 3 个循环的杀菌效率约为 93.8%，细菌释放率约为 83.1%。本研究中提出的光致可切换抗菌表面将为智能生物医学表面的开发提供新的思路。
