Moreno-Juan Verónica, Aníbal-Martínez Mar, Herrero-Navarro Álvaro, Valdeolmillos Miguel, Martini Francisco J, López-Bendito Guillermina
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain.
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain.
Neuroscience. 2023 Jan 1;508:87-97. doi: 10.1016/j.neuroscience.2022.07.022. Epub 2022 Jul 22.
Sensory processing relies on the correct development of thalamocortical loops. Visual corticothalamic axons (CTAs) invade the dorsolateral geniculate nucleus (dLGN) of the thalamus in early postnatal mice according to a regulated program that includes activity-dependent mechanisms. Spontaneous retinal activity influences the thalamic incursion of CTAs, yet the perinatal thalamus also generates intrinsic patterns of spontaneous activity whose role in modulating afferent connectivity remains unknown. Here, we found that patterned spontaneous activity in the dLGN contributes to proper spatial and temporal innervation of CTAs. Disrupting patterned spontaneous activity in the dLGN delays corticogeniculate innervation under normal conditions and upon eye enucleation. The delayed innervation was evident throughout the first two postnatal weeks but resumes after eye-opening, suggesting that visual experience is necessary for the homeostatic recovery of corticogeniculate innervation.
感觉处理依赖于丘脑皮质环路的正确发育。视觉皮质丘脑轴突（CTAs）在出生后早期的小鼠中，按照一个包括活动依赖机制的调控程序侵入丘脑的背外侧膝状体核（dLGN）。视网膜自发活动会影响CTAs向丘脑的侵入，然而围产期丘脑也会产生自发活动的内在模式，其在调节传入连接中的作用尚不清楚。在这里，我们发现dLGN中有模式的自发活动有助于CTAs进行适当的空间和时间支配。在正常条件下以及眼球摘除后，破坏dLGN中有模式的自发活动会延迟皮质膝状体神经支配。这种延迟的神经支配在出生后的前两周都很明显，但在睁眼后恢复，这表明视觉经验对于皮质膝状体神经支配的稳态恢复是必要的。
