Health Management Center, Taizhou Central Hospital (Taizhou University Hospital), No. 999 Donghai Avenue, Taizhou Economic Development Zone, Taizhou, Zhejiang Province 318000, PR China.
High Dimensional Digital Medicine Division, Biovisualab, Lotus International Plaza, 7866 Humin Road, Shanghai 201102, PR China.
Diabetes Res Clin Pract. 2022 Aug;190:110021. doi: 10.1016/j.diabres.2022.110021. Epub 2022 Jul 22.
To learn how high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) are associated with fasting blood glucose (FBG).
A cross-sectional study was performed in 97,801 males and 70,773 females without known disease.
The ratio of HDL-C/ApoA-I is more stable for predicting fasting glucose levels than HDL-C or ApoA-I alone. In subjects with HDL-C/ApoA-I ≤ 0.9, HDL-C/ApoA-I ratios were negatively associated with FBG levels, with similar patterns between sexes, and the associations gradually strengthened along with the deciles of FBG increase. In subjects with HDL-C/ApoA-I > 0.9, FBG remained at relatively lower levels in both sexes, while the associations between the FBG level and the HDL-C/ApoA-I ratio turned from negative in the lowest five deciles to positive in the highest two deciles of FBG levels in males. Adjustment for known confounders only slightly attenuated the above association patterns. Subpopulations with HDL-C/ApoA-I ≤ 0.9 were distributed in the higher ranges of triglyceride (TG), non-HDL-C, total cholesterol (TC) and ApoA-I levels and lower ranges of HDL-C levels.
The HDL-C/ApoA-I ratio sorted TG, non-HDL-C, TC, ApoA-I and HDL-C levels and hence might combine more coordinating metabolic characteristics of these lipids in association with blood glucose homeostasis.
了解高密度脂蛋白胆固醇（HDL-C）和载脂蛋白 A-I（ApoA-I）与空腹血糖（FBG）的关系。
本研究为横断面研究，共纳入 97801 名男性和 70773 名女性，所有研究对象均无已知疾病。
与单独的 HDL-C 或 ApoA-I 相比，HDL-C/ApoA-I 比值在预测空腹血糖水平方面更稳定。在 HDL-C/ApoA-I≤0.9 的受试者中，HDL-C/ApoA-I 比值与 FBG 水平呈负相关，且在性别间具有相似的模式，随着 FBG 水平升高的十分位数增加，这种相关性逐渐增强。在 HDL-C/ApoA-I＞0.9 的受试者中，男女的 FBG 水平均处于相对较低的水平，而在 FBG 水平的前五个十分位数中，HDL-C/ApoA-I 比值与 FBG 水平之间的相关性为负相关，在 FBG 水平的后两个十分位数中，这种相关性转为正相关。仅调整已知混杂因素后，上述关联模式略有减弱。HDL-C/ApoA-I≤0.9 的亚组分布在 TG、非 HDL-C、TC 和 ApoA-I 水平较高和 HDL-C 水平较低的范围内。
HDL-C/ApoA-I 比值可对 TG、非 HDL-C、TC、ApoA-I 和 HDL-C 水平进行排序，并可能结合这些血脂与血糖稳态相关的更多协调代谢特征。
