Jakobiec F A, Harrison W, Aronian D
Ophthalmology. 1987 Mar;94(3):283-7. doi: 10.1016/s0161-6420(87)33459-1.
Juxtalimbal epibulbar inverted papillomas that were locally excised without recurrence developed in two women, aged 42 and 51 at the time of initial presentation. There is only one previous report of this unusual conjunctival neoplasm, which documented involvement of the plical, caruncular, or tarsal conjunctiva. The tumor grew by acanthosis of the surface nonkeratinizing squamous epithelium, with invagination into the underlying connective tissue in the absence of inflammation or a tendency toward keratinization. The initial invaginations may be cystic in character, but solid lobules secondarily originated from their walls to push into the connective tissue. Mucus-producing goblet cells were scattered throughout the lesions; highly distinctive eosinophilic globoid bodies, probably reflecting inspissated mucoid material, were found in the walls of the cysts and entrapped within their secretions. Conjunctival inverted papilloma does not exhibit locally aggressive behavior, does not involve extensive segments of the conjunctival epithelium, and does not display diffuse spread or multicentricity. The authors therefore believe that it should be clearly separated from inverted squamous (Schneiderian) papillomas of the nasal cavity and sinuses.
两名女性在初次就诊时分别为42岁和51岁，她们均患有近角膜缘的球结膜内翻乳头状瘤，经局部切除后未复发。此前仅有一篇关于这种罕见结膜肿瘤的报道，该报道记录了其累及皱襞、泪阜或睑结膜的情况。肿瘤由表面非角化鳞状上皮的棘皮症生长而来，在无炎症或角化倾向的情况下向下方结缔组织内陷。最初的内陷可能呈囊性，但随后从其壁上长出实性小叶并向结缔组织内推进。产生黏液的杯状细胞散在于整个病变中；在囊肿壁内及分泌物中发现了高度独特的嗜酸性球状小体，可能反映了浓缩的黏液样物质。结膜内翻乳头状瘤不表现出局部侵袭性行为，不累及结膜上皮的大片区域，也不表现为弥漫性扩散或多中心性。因此，作者认为它应与鼻腔和鼻窦的内翻性鳞状（施耐德氏）乳头状瘤明确区分开来。
