Lebon A, Connault J, Cardaillac C, Thubert T, Winer N, Dochez V
Service de gynécologie-obstétrique, CH de Saint-Nazaire, Saint-Nazaire, France.
Service de médecine interne, CHU de Nantes, Nantes, France.
Rev Med Interne. 2022 Aug;43(8):462-469. doi: 10.1016/j.revmed.2022.07.005. Epub 2022 Jul 22.
Postpartum ovarian vein thrombosis (POVT) is a rare but serious postpartum complication that can be life-threatening due to its embolic and septic risks. The clinical and paraclinical diagnosis is difficult because of the non-specific signs and the absence of a gold standard for imaging. There is no consensus in the literature on the treatment and follow-up of these patients. The primary objective was to specify the clinical and paraclinical signs suggestive of POVT in order to improve the diagnostic delay. The secondary objectives were to describe the extent of POVT and the proposed immediate therapeutic management.
This was a 10-year retrospective study in a type III maternity hospital, from January 2010 to December 2019, where all patients with an imaging-confirmed diagnosis of POVT were included. We analysed the clinical and paraclinical data and the follow-up of the patients.
We included 9 patients with a diagnostic confirmation by imaging. The mean time from first symptoms to diagnosis was 3.3 days (±3.5 days), and only 2 patients (22.2 %) had been diagnosed with POVT before imaging. All patients received curative anticoagulation and 77.8 % (n=7) received antibiotic therapy for POVT. Two patients had a complicated form, 1 with a pulmonary embolism and 1 with a urinary tract compression requiring a urinary diversion with a double J catheter. Five patients (55.6 %) had a thrombophilia check-up.
The diagnosis of POVT is difficult and needs to be evoked in front of a painful symptomatology or a fever in postpartum. It can be made by ultrasound, but the injected CT scan specifying the specific search for a POVT remains the imaging examination of choice in order to confirm the diagnosis and eliminate differential diagnoses. Under curative anticoagulation and broad-spectrum antibiotic therapy, the clinical course is generally very favourable. A consultation with an internist makes it possible to define instructions for a subsequent pregnancy.
产后卵巢静脉血栓形成(POVT)是一种罕见但严重的产后并发症,因其存在栓塞和感染风险,可能危及生命。由于症状不具特异性且缺乏影像学诊断的金标准,临床及辅助检查诊断较为困难。目前关于这些患者的治疗及随访,文献中尚无共识。主要目的是明确提示POVT的临床及辅助检查体征,以缩短诊断延迟。次要目的是描述POVT的范围及建议的即刻治疗管理。
这是一项在一家三级妇产医院进行的为期10年的回顾性研究,时间跨度为2010年1月至2019年12月,纳入所有经影像学确诊为POVT的患者。我们分析了患者的临床及辅助检查数据以及随访情况。
我们纳入了9例经影像学确诊的患者。从首次出现症状到确诊的平均时间为3.3天(±3.5天),仅有2例患者(22.2%)在影像学检查前被诊断为POVT。所有患者均接受了治疗性抗凝,77.8%(n = 7)的患者因POVT接受了抗生素治疗。2例患者病情复杂,1例发生肺栓塞,1例因尿路受压需要通过双J导管进行尿液改道。5例患者(55.6%)进行了血栓形成倾向检查。
POVT的诊断较为困难,产后出现疼痛症状或发热时需考虑该病。超声检查可进行初步诊断,但为明确诊断并排除鉴别诊断,增强CT扫描仍是首选的影像学检查,因其能针对性地查找POVT。在进行治疗性抗凝和广谱抗生素治疗后,临床病程通常非常良好。咨询内科医生有助于为后续妊娠制定指导方案。