Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Trends Endocrinol Metab. 2022 Sep;33(9):639-651. doi: 10.1016/j.tem.2022.06.001. Epub 2022 Jul 22.
Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving mutational landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our knowledge of EC biology by focusing on the role of androgen hormones. First, we discuss epidemiological evidence implicating androgens with EC pathogenesis and cover their biosynthesis and metabolism to bioactive 11-oxyandrogens. Next, we explore the endometrial tumor tissue and the altered microbiota as alternative sources of androgens and their 11-oxymetabolites in EC patients. Finally, we discuss the biological significance of androgens' genomic and nongenomic signaling as part of a medley of pathways ultimately deciding the fate of cells.
子宫内膜癌（EC）是一种影响子宫内层的妇科病理学。近年来，基因组研究揭示了子宫内膜肿瘤不断演变的突变景观，为制定治疗策略提供了巨大的潜力。本综述旨在通过关注雄激素激素的作用，拓宽我们对 EC 生物学的认识。首先，我们讨论了流行病学证据，将雄激素与 EC 的发病机制联系起来，并涵盖了它们的生物合成和代谢到生物活性 11-氧基雄激素。接下来，我们探讨了子宫内膜肿瘤组织和改变的微生物群作为雄激素及其在 EC 患者中的 11-氧代谢物的替代来源。最后，我们讨论了雄激素的基因组和非基因组信号的生物学意义，作为最终决定细胞命运的多种途径的一部分。
