Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Handb Exp Pharmacol. 2023;278:181-198. doi: 10.1007/164_2022_602.
This chapter explores the existing structural and functional studies on the endo-lysosomal channel TRPML1 and its analogs TRPML2, TRPML3. These channels represent the mucolipin subfamily of the TRP channel superfamily comprising important roles in sensory physiology, ion homeostasis, and signal transduction. Since 2016, numerous structures have been determined for all three members using either cryo-EM or X-ray crystallography. These studies along with recent functional analysis have considerably strengthened our knowledge on TRPML channels and its related endo-lysosomal function. This chapter, together with relevant reports in other chapters from this handbook, provides an informative and detailed tool to study the endo-lysosomal cation channels.
本章探讨了内体溶酶体通道 TRPML1 及其类似物 TRPML2、TRPML3 的现有结构和功能研究。这些通道构成了 TRP 通道超家族的粘脂蛋白亚家族，在感觉生理学、离子稳态和信号转导中发挥着重要作用。自 2016 年以来，使用冷冻电镜或 X 射线晶体学已经确定了所有三个成员的许多结构。这些研究以及最近的功能分析极大地增强了我们对 TRPML 通道及其相关内体溶酶体功能的了解。本章与本手册其他章节中的相关报告一起，为研究内体溶酶体阳离子通道提供了一个信息丰富和详细的工具。
