Fan Su, Fang Yi-Gong
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhen Ci Yan Jiu. 2022 Jul 25;47(7):644-8. doi: 10.13702/j.1000-0607.20210330.
Diminished ovarian reserve (DOR) is the main cause of female infertility. Acupuncture has a significant clinical effect on DOR. This article reviews the signal pathways, e.g. PI3K/Akt, Nrf2/ARE, Bcl-2/Caspase-3 regulated with acupuncture in 3 aspects, i.e. the structure and signal transduction of each pathway,the relationship with ovarian reserve and the improvement of acupuncture in ovarian reserve. It is anticipated to provide a new approach to further exploring the mechanism of acupuncture on the improvement of ovarian reserve. Moreover, the evidences of acupuncture may be obtained for its clinical treatment of DOR and other reproductive endocrine diseases.
卵巢储备功能减退（DOR）是女性不孕的主要原因。针灸对DOR有显著的临床疗效。本文从PI3K/Akt、Nrf2/ARE、Bcl-2/Caspase-3等信号通路在结构与信号转导、与卵巢储备的关系以及针灸对卵巢储备的改善作用这3个方面，综述针灸对这些信号通路的调节作用。期望为进一步探索针灸改善卵巢储备功能的机制提供新的途径。此外，可为针灸临床治疗DOR及其他生殖内分泌疾病提供依据。
