Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.
Department of Otorhinolaryngology and Head & Neck Surgery, International Islamic University Malaysia.
Acta Otorhinolaryngol Ital. 2022 Jun;42(3):250-256. doi: 10.14639/0392-100X-N1981.
To determine the serum levels of interleukin-1beta (IL-1β) in patients with acquired laryngotracheal stenosis (ALTS) and healthy volunteers and compare levels between serum and tissue of the stenotic segment.
An exploratory cohort study included 20 participants with ALTS and 5 healthy volunteers. ALTS group was categorised into mild and severe according to grade of stenosis and presence of tracheostomy. Comparisons of serum levels of IL-1β between pre- and post-surgical intervention and between blood and tissue samples in the severe ALTS group were made. Correlation of IL-1β levels between blood and tissue was assessed using Spearman's correlation.
Severe ALTS patients showed higher serum levels of IL-1β compared to mild ALTS and healthy volunteers (p = 0.045). IL-1β was higher before surgical intervention than after surgical intervention (p = 0.003). There was a strong positive correlation of IL-1β between serum and tissue (r = 0.74, p = 0.035).
Serum levels of IL-1β are higher in ALTS patients than in healthy controls and positively correlate with tissue levels. The decreasing trend of serum IL-1β observed following successful surgical intervention reflects the absence of ongoing inflammation at the stenotic segment.
检测获得性喉气管狭窄（ALTS）患者与健康志愿者血清中白细胞介素-1β（IL-1β）的水平，并比较狭窄段血清与组织中的水平。
本研究为探索性队列研究，共纳入 20 名 ALTS 患者和 5 名健康志愿者。根据狭窄程度和是否存在气管造口术，将 ALTS 组分为轻度和重度。比较重度 ALTS 组患者手术前后、血液与组织样本中 IL-1β 的血清水平。采用 Spearman 相关分析评估 IL-1β 水平在血液与组织之间的相关性。
与轻度 ALTS 患者和健康志愿者相比，重度 ALTS 患者的血清 IL-1β 水平更高（p = 0.045）。手术前的 IL-1β 水平高于手术后（p = 0.003）。血清与组织中的 IL-1β 呈强烈正相关（r = 0.74，p = 0.035）。
ALTS 患者的血清 IL-1β 水平高于健康对照组，且与组织水平呈正相关。成功手术后血清 IL-1β 水平呈下降趋势，反映了狭窄段炎症的消失。
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