Department of Molecular Biology, Marmara University Faculty of Arts and Science, Istanbul, 34722, Turkey.
Department of Medical Oncology, Demiroglu Bilim University Faculty of Medicine, Istanbul, 34394, Turkey.
Per Med. 2022 Sep;19(5):435-444. doi: 10.2217/pme-2021-0047. Epub 2022 Jul 26.
To investigate the association of , and polymorphisms on 5-fluorouracil (5-FU) related toxicities and patient survival. A total of 103 colorectal cancer patients prescribed 5-FU were included in the study. Genotyping was conducted for several , and polymorphisms using a microarray analyzer. 496A>G polymorphism was found to be significantly associated with 5-FU related grade 0-2, but not severe toxicities (p = 0.02). Furthermore, patients with 85TC and CC genotypes had longer progression and overall survival times compared to TT genotypes in our study group (log rank = 6.60; p = 0.01 and log rank = 4.40; p = 0.04, respectively). According to our results, 496AG and GG genotypes might be protective against severe adverse events compared to the AA genotype. Another polymorphism, 85T>C, may be useful in colorectal cancer prognosis. Further studies for both polymorphisms should be conducted in larger populations to achieve accurate results.
为了研究 、 和 多态性与 5-氟尿嘧啶（5-FU）相关毒性和患者生存的关联。本研究纳入了 103 名接受 5-FU 治疗的结直肠癌患者。使用微阵列分析仪对几种 、 和 多态性进行了基因分型。496A>G 多态性与 5-FU 相关的 0-2 级毒性显著相关，但与严重毒性无关（p=0.02）。此外，与 TT 基因型相比，85TC 和 CC 基因型的患者在我们的研究组中具有更长的进展和总生存时间（对数秩检验=6.60；p=0.01 和对数秩检验=4.40；p=0.04）。根据我们的结果，与 AA 基因型相比，496AG 和 GG 基因型可能对严重不良事件具有保护作用。另一种 多态性 85T>C 可能对结直肠癌的预后有用。应在更大的人群中对这两种多态性进行进一步研究，以获得准确的结果。
