Duiverman E J, Neijens H J, van Strik R, Affourtit M J, Kerrebijn K F
Pediatr Pulmonol. 1987 Jan-Feb;3(1):38-44. doi: 10.1002/ppul.1950030111.
A number of studies have shown that children who had infantile bronchiolitis are at increased risk of recurrent episodes of wheezing. A genetic predisposition to atopy is mentioned in some studies and is contested by others. Lung function abnormalities and increased bronchial responsiveness (BR) have been described after infantile bronchiolitis. We investigated children who had had the clinical syndrome of bronchiolitis during infancy and compared them with asthmatic and healthy children of the same age regarding bronchial caliber, smooth muscle tone, and responsiveness to histamine. Lung function was measured by forced oscillometry. We found that most children with current symptoms had either decreased baseline bronchial caliber, increased bronchial smooth muscle tone, or increased BR. These patients are comparable to mild asthmatics. The children without current symptoms are comparable to healthy children in these respects. Recurrent respiratory symptoms after bronchiolitis should be regarded as mild asthma and treated as such.
多项研究表明，曾患婴儿细支气管炎的儿童出现反复喘息发作的风险增加。一些研究提到了特应性的遗传易感性，而另一些研究则对此提出质疑。婴儿细支气管炎后出现了肺功能异常和支气管反应性（BR）增加的情况。我们对婴儿期曾患细支气管炎临床综合征的儿童进行了调查，并将他们与同龄哮喘儿童和健康儿童在支气管管径、平滑肌张力以及对组胺的反应性方面进行了比较。通过强迫振荡法测量肺功能。我们发现，大多数有当前症状的儿童要么基线支气管管径减小、支气管平滑肌张力增加，要么支气管反应性增加。这些患者与轻度哮喘患者相当。在这些方面，没有当前症状的儿童与健康儿童相当。细支气管炎后的反复呼吸道症状应被视为轻度哮喘并按此进行治疗。
