哮喘患儿支气管反应性评估中潮气呼吸法和剂量计法的结果是否取决于年龄？
Does the outcome of the tidal breathing and dosimeter methods of assessing bronchial responsiveness in children with asthma depend on age?
作者信息
Birnie D, thoe Schwartzenberg G W, Hop W C, van Essen-Zandvliet E E, Kerrebijn K F
机构信息
Division of Paediatric Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands.
出版信息
Thorax. 1990 Mar;45(3):199-202. doi: 10.1136/thx.45.3.199.
As minute volume increases with age, a study was carried out to determine whether the measurement of bronchial responsiveness to pharmacological agents with the tidal breathing technique in children might be influenced by age. Bronchial responsiveness to histamine administered by tidal breathing was therefore compared with that produced with a dosimeter in 25 children with asthma aged 5-18 years. Bronchial responsiveness was defined as the concentration of histamine that caused a 40% rise in pulmonary resistance (PC40) measured by random noise forced oscillation at 6 Hz. Values of PC40 measured by the tidal breathing method were lower than those obtained with the dosimeter method, presumably owing to differences in the dose administered and variations in the pattern of breathing. The difference between the two methods was not related to age, however. It is concluded that the tidal breathing and the dosimeter methods are both suitable for the measurement of bronchial responsiveness in children of various ages and that both can be used in longitudinal studies.
随着分钟通气量随年龄增加，开展了一项研究以确定在儿童中采用潮气呼吸技术测量支气管对药物的反应性是否会受年龄影响。因此，对25名年龄在5至18岁的哮喘儿童采用潮气呼吸给予组胺后的支气管反应性与用剂量仪产生的支气管反应性进行了比较。支气管反应性定义为通过6赫兹随机噪声强迫振荡测量导致肺阻力升高40%的组胺浓度（PC40）。用潮气呼吸法测得的PC40值低于用剂量仪法获得的值，这可能是由于给药剂量不同以及呼吸模式变化所致。然而，两种方法之间的差异与年龄无关。结论是，潮气呼吸法和剂量仪法均适用于测量不同年龄儿童的支气管反应性，且二者均可用于纵向研究。
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