Department of Orthopedics, Taipei Veterans General Hospital, Taipei, Taiwan ROC.
Department of Senior Services Industry Management, Minghsin University of Science and Technology, Hsinchu, Taiwan ROC.
Int J Rheum Dis. 2022 Aug;25(8):937-944. doi: 10.1111/1756-185X.14393. Epub 2022 Jul 26.
To investigate the association between ankylosing spondylitis (AS) and alopecia.
In this cohort study, data from over 1 000 000 patients in the Taiwan Longitudinal Health Insurance Database were extracted. We selected newly diagnosed (outpatient department visit three or more times or admission at least once) patients with AS (ICD-9-CM = 720.0) from 2000 to 2012. For the non-AS comparison group, patients never diagnosed with AS were chosen from 1999 to 2013. In all, 3640 AS patients and 14 560 non-AS controls were selected. Cox proportional hazard model and Kaplan-Meier analysis were used to present the results. The adjusted hazard ratio (HR) in the Cox proportional hazard model was adjusted for age, sex, hypertension, hyperlipidemia, diabetes, atopic dermatitis, and mental disorder.
No increased risk of alopecia in AS patients was shown in the Cox proportional hazard model (crude HR 1.16, P = 0.595; adjusted HR 1.16, P = 0.599). Negative results are found as well in subgroup analysis of different age, sex (age 20-40 y: HR 1.03, P = 0.925; Age ≥40 y: HR 1.49, P = 0.406; Female: HR 1.17, P = 0.759; Male: HR 1.15, P = 0.667), and phenotypes of alopecia (androgenetic alopecia: HR 1.19, 95% confidence interval [CI] 0.58-2.41; alopecia areata: HR 0.98, 95% CI 0.37-2.62). A significant positive correlation is found between atopic dermatitis and alopecia (adjusted HR 8.05, P = 0.039).
In this population-based cohort study, we found no association of risk of alopecia and AS.
探讨强直性脊柱炎（AS）与脱发之间的关联。
本队列研究从台湾地区纵向健康保险数据库中提取了超过 100 万患者的数据。我们从 2000 年至 2012 年选择了新诊断的（门诊就诊 3 次或以上或至少入院 1 次）AS 患者（ICD-9-CM 720.0）。对于非 AS 对照组，我们从 1999 年至 2013 年选择了从未被诊断为 AS 的患者。总共选择了 3640 例 AS 患者和 14560 例非 AS 对照组。采用 Cox 比例风险模型和 Kaplan-Meier 分析呈现结果。Cox 比例风险模型中的调整后风险比（HR）调整了年龄、性别、高血压、高血脂、糖尿病、特应性皮炎和精神障碍。
Cox 比例风险模型未显示 AS 患者脱发风险增加（粗 HR 1.16，P=0.595；调整 HR 1.16，P=0.599）。亚组分析显示，在不同年龄、性别（20-40 岁：HR 1.03，P=0.925；年龄≥40 岁：HR 1.49，P=0.406；女性：HR 1.17，P=0.759；男性：HR 1.15，P=0.667）和脱发表型（雄激素性脱发：HR 1.19，95%置信区间 [CI] 0.58-2.41；斑秃：HR 0.98，95% CI 0.37-2.62）中，结果也为阴性。特应性皮炎与脱发之间存在显著正相关（调整后 HR 8.05，P=0.039）。
在这项基于人群的队列研究中，我们未发现脱发与 AS 之间存在风险关联。
