Rybakova M G, Mylnikova A A, Vlasova M T
Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.
Arkh Patol. 2022;84(4):51-55. doi: 10.17116/patol20228404151.
IgG4-related disease is an immune-mediated disorder with tumor-like multiorgan involvement, elevated serum IgG4 level and specific histopathological appearance (lymphoplasmacytic infiltrate rich in IgG4+ plasma cells and storiform fibrosis). The article presents rare clinical and morphological observations of IgG4-related mastopathy in women with suspected tumor process. A strategy for the treatment of IgG4-related disease should be based on the results of pre-surgery histopathological examination, which may help to avoid unreasonable surgical intervention and choose glucocorticoids or rituximab as the first-line treatment.
IgG4相关性疾病是一种免疫介导的疾病，伴有肿瘤样多器官受累、血清IgG4水平升高以及特定的组织病理学表现（富含IgG4+浆细胞的淋巴浆细胞浸润和席纹状纤维化）。本文报道了疑似肿瘤性病变的女性患者中IgG4相关性乳腺病罕见的临床和形态学观察结果。IgG4相关性疾病的治疗策略应基于术前组织病理学检查结果，这有助于避免不合理的手术干预，并选择糖皮质激素或利妥昔单抗作为一线治疗。
