Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Dentistry, Changhua Christian Hospital, Changhua, Taiwan.
J Oral Pathol Med. 2022 Sep;51(8):730-737. doi: 10.1111/jop.13337. Epub 2022 Aug 15.
To evaluate the associations between dipeptidyl peptidase IV (DPP4) single-nucleotide polymorphism (SNP) and clinicopathological characteristics of oral cancer.
Four loci of DPP4 SNPs (rs7608798 A/G, rs3788979 C/T, rs2268889 T/C, and rs6741949 G/C) were genotyped by using the TaqMan allelic discrimination in 1238 oral cancers patients and 1197 non-cancer individuals.
The percentage of DPP4 SNP rs2268889 TC + CC was significantly higher in the oral cancer participants compared to the control group (odds ratio [OR]: 1.178, 95% confidence interval (CI): 1.004-1.382, p = 0.045). Among 1676 smokers, DPP4 polymorphisms carriers with betel quid chewing were found to have an 8.785- to 10.903-fold risk to have oral cancer compared to DPP4 wild-type carriers without betel quid chewing. Similar trend was found in individuals with alcohol consumption. Moreover, the oral cancer individuals without cigarette smoking history with at least one varied C allele of DPP4 rs2268889 had a significantly higher percentage of large tumor size with the wild-type TT homozygote (p = 0.011).
The DPP4 SNP may correlate to the development of oral cancer in those with cigarette smoking and alcohol consumption. Besides, the DPP4 SNP rs2268889 could relate to worse clinical course of oral cancer in non-smokers.
评估二肽基肽酶 4（DPP4）单核苷酸多态性（SNP）与口腔癌临床病理特征的关系。
采用 TaqMan 等位基因鉴别法对 1238 例口腔癌患者和 1197 例非癌症个体的 DPP4 4 个 SNP（rs7608798 A/G、rs3788979 C/T、rs2268889 T/C 和 rs6741949 G/C）进行基因分型。
与对照组相比，口腔癌患者 DPP4 SNP rs2268889 TC+CC 的比例明显更高（比值比 [OR]：1.178，95%置信区间 [CI]：1.004-1.382，p=0.045）。在 1676 名吸烟者中，与 DPP4 野生型携带者相比，嚼槟榔的 DPP4 多态性携带者患口腔癌的风险增加 8.785-10.903 倍。在饮酒者中也发现了类似的趋势。此外，无吸烟史且至少有一个 DPP4 rs2268889 变异 C 等位基因的口腔癌患者，其野生型 TT 纯合子的大肿瘤大小比例明显更高（p=0.011）。
DPP4 SNP 可能与有吸烟和饮酒习惯的人发生口腔癌有关。此外，DPP4 SNP rs2268889 可能与不吸烟者口腔癌的临床病程较差有关。
