基于社区的研究：乳腺癌患者化疗相关认知障碍的对比分析。
Comparative Analysis of the Chemotherapy-Related Cognitive Impairments in Patients with Breast Cancer: A Community-Based Research.
机构信息
Students' Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Cancer Invest. 2022 Oct;40(9):811-821. doi: 10.1080/07357907.2022.2106489. Epub 2022 Aug 8.
This study aimed to evaluate the effects of two common chemotherapy regimens on breast cancer (BC) survivors' cognition. The participants comprised 35 patients with BC who underwent two chemotherapy regimens, AC-T and TAC, and 24 matched healthy volunteers. The participants were assessed regarding cognitive function through Addenbrooke's Cognitive Examination and Cambridge Brain Science tests. The results represent the AC-T regimen to be more toxic than the TAC in domains of language, concentration, and visuospatial working memory (-value = 0.036, 0.008, and 0.031, respectively) and should be prescribed with caution in patients with BC suffering from baseline cognitive impairments.
本研究旨在评估两种常见化疗方案对乳腺癌（BC）幸存者认知功能的影响。参与者包括 35 名接受 AC-T 和 TAC 两种化疗方案的 BC 患者和 24 名匹配的健康志愿者。通过 Addenbrooke 认知评估和剑桥脑科学测试评估参与者的认知功能。结果表明，AC-T 方案在语言、注意力和视空间工作记忆方面比 TAC 方案毒性更大（-值分别为 0.036、0.008 和 0.031），因此对于基线认知功能受损的 BC 患者应谨慎处方。
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