脑内糖质淋液系统的溶质转运和废物清除的生理学。
Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain.
机构信息
Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.
Departments of Computer Science and Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York.
出版信息
Physiology (Bethesda). 2022 Nov 1;37(6):0. doi: 10.1152/physiol.00015.2022. Epub 2022 Jul 26.
Abstract
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.
摘要
这篇综述重点介绍了神经胶质淋巴系统（glymphatic system）中溶质转运和废物清除的生理学，使用了来自实验动物模型和人类研究的证据。具体讨论的主题包括中枢神经系统中液体和溶质转运的生物物理特性、神经胶质淋巴耦合（glymphatic-lymphatic coupling），以及脑脊液流动对大脑废物清除的作用。我们还讨论了目前对睡眠期间废物清除增加的机制的理解。
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