Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries.
作者信息
Chen Xinan, Liu Xiaodan, Koundal Sunil, Elkin Rena, Zhu Xiaoyue, Monte Brittany, Xu Feng, Dai Feng, Pedram Maysam, Lee Hedok, Kipnis Jonathan, Tannenbaum Allen, Van Nostrand William E, Benveniste Helene
机构信息
Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.
出版信息
Nat Aging. 2022 Mar;2(3):214-223. doi: 10.1038/s43587-022-00181-4. Epub 2022 Mar 7.
Abstract
摘要
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Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries.脑淀粉样血管病与类淋巴系统转运减少及沿颈动脉溶质引流延迟有关。
Nat Aging. 2022 Mar;2(3):214-223. doi: 10.1038/s43587-022-00181-4. Epub 2022 Mar 7.
2
Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries.作者更正：脑淀粉样血管病与类淋巴系统转运减少及沿颈部动脉的溶质引流延迟有关。
Nat Aging. 2023 Dec;3(12):1603. doi: 10.1038/s43587-023-00544-5.
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Publisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries.出版商更正：脑淀粉样血管病与淋巴系统转运减少及沿颈动脉溶质引流延迟有关。
Nat Aging. 2022 May;2(5):454. doi: 10.1038/s43587-022-00223-x.
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Cell. 2021 Feb 18;184(4):1000-1016.e27. doi: 10.1016/j.cell.2020.12.040. Epub 2021 Jan 27.
3
Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular-interstitial flux through the cortical mantle.沿血管树不同的血管周围星形胶质细胞终足尺寸维持了通过皮质套的血管周围-间质通量。
Glia. 2021 Mar;69(3):715-728. doi: 10.1002/glia.23923. Epub 2020 Oct 19.
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Circadian control of brain glymphatic and lymphatic fluid flow.昼夜节律对脑内糖质淋巴和淋巴液流动的控制。
Nat Commun. 2020 Sep 2;11(1):4411. doi: 10.1038/s41467-020-18115-2.
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Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease.脑膜免疫及其在中枢神经系统健康和疾病中的功能。
Annu Rev Immunol. 2020 Apr 26;38:597-620. doi: 10.1146/annurev-immunol-102319-103410.
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Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy.载脂蛋白 E 转基因 -DI 大鼠，一种新的微小血管性脑淀粉样血管病模型，具有较强的神经炎症和血管周围病理学特征。
J Neuroinflammation. 2020 Mar 4;17(1):78. doi: 10.1186/s12974-020-01755-y.
7
Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System.拉格朗日工作流的最优质量传输揭示了在神经胶质淋巴系统中溶质的对流和扩散驱动传输。
Sci Rep. 2020 Feb 6;10(1):1990. doi: 10.1038/s41598-020-59045-9.
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Impaired Glymphatic Transport in Spontaneously Hypertensive Rats.自发性高血压大鼠的糖质分解液转运功能受损。
J Neurosci. 2019 Aug 7;39(32):6365-6377. doi: 10.1523/JNEUROSCI.1974-18.2019. Epub 2019 Jun 17.
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Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.在麻醉状态下的小鼠中，糖质淋流增加与 EEG 德尔塔功率高和心率低相关。
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